Estring and Vaginal bleeding between periods - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding between periods is reported as a side effect among people who take Estring (estradiol), especially for people who are 60+ old, have been taking the drug for < 1 month also take Prempro, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Vaginal bleeding between periods when taking Estring. It is created by eHealthMe based on reports of 5,418 people who have side effects when taking Estring from the FDA, and is updated regularly.

What is Estring?

Estring has active ingredients of estradiol. eHealthMe is studying from 5,474 Estring users. Check the latest studies of Estring.

What is Vaginal bleeding between periods?

Vaginal bleeding between periods is found to be associated with 573 drugs and 1,471 conditions by eHealthMe. Check the latest studies of Vaginal bleeding between periods.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

5,418 people reported to have side effects when taking Estring.
Among them, 19 people (0.35%) have Vaginal bleeding between periods.

Could Estring cause Vaginal bleeding between periods?

Among these 19 people:

How long have people been on Estring when they have Vaginal bleeding between periods? *

What is the age of people who have Vaginal bleeding between periods when taking Estring? *

What are other drugs people take besides Estring? *

Wellbutrin: 2 people, 10.53%
Simvastatin: 2 people, 10.53%
Prempro: 2 people, 10.53%
Synthroid: 1 person, 5.26%
Sertraline Hydrochloride: 1 person, 5.26%
Restoril: 1 person, 5.26%
Prozac: 1 person, 5.26%
Norvasc: 1 person, 5.26%
Lipitor: 1 person, 5.26%
Furosemide: 1 person, 5.26%

What are other side effects people have besides Vaginal bleeding between periods? *

Vulvovaginal Discomfort: 5 people, 26.32%
Vulvovaginal Dryness: 4 people, 21.05%
Postmenopause: 4 people, 21.05%
Pain: 4 people, 21.05%
Uterine Mass: 2 people, 10.53%
Ovarian Cysts (fluid filled sacs of the ovary): 2 people, 10.53%
Breast Lump (localized swelling that feels different from the surrounding breast tissue): 2 people, 10.53%
Axillary Mass: 2 people, 10.53%
Polyp: 1 person, 5.26%
Pelvic Pain: 1 person, 5.26%

What are the existing conditions these people have? *

Vulvovaginal Dryness: 4 people, 21.05%
Vaginal Bleeding: 4 people, 21.05%
Uterine Prolapse: 4 people, 21.05%
High Blood Cholesterol: 4 people, 21.05%
Menopausal Symptoms: 2 people, 10.53%
Atrophic Vulvovaginitis (inflammation of the vulva): 2 people, 10.53%
Vaginal Infection: 1 person, 5.26%
Sexual Intercourse - Painful: 1 person, 5.26%
Menopause (end of monthly cycles in women): 1 person, 5.26%
Depression: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Estring and have Vaginal bleeding between periods?

- Check whether Vaginal bleeding between periods is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estring:

Estring (5,474 reports)

Browse all side effects of Estring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (573 drugs)

Browse all the conditions that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (1,471 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estring) and Estring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.