Estrogel and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Estrogel (estradiol), especially for people who are female, 30-39 old, have been taking the drug for 2 - 5 years also take Ocrevus, and have Osteoporosis.

The phase IV clinical study analyzes which people have Fluid retention when taking Estrogel. It is created by eHealthMe based on reports of 2,659 people who have side effects when taking Estrogel from the FDA, and is updated regularly.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,922 Estrogel users. Check the latest studies of Estrogel.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,698 drugs and 2,449 conditions by eHealthMe. Check the latest studies of Fluid retention.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 28, 2026

2,659 people reported to have side effects when taking Estrogel.
Among them, 20 people (0.75%) have Fluid retention.

Among these 20 people:

How long have people been on Estrogel when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Estrogel? *

female: 100 %
male: 0.0 %

What is the age of people who have Fluid retention when taking Estrogel? *

What are other drugs people take besides Estrogel? *

What are other side effects people have besides Fluid retention? *

Fatigue (feeling of tiredness): 13 people, 65.00%
Joint Pain: 13 people, 65.00%
Headache (pain in head): 12 people, 60.00%
Nausea (feeling of having an urge to vomit): 11 people, 55.00%
Weight Decreased: 10 people, 50.00%
Chest Pain: 10 people, 50.00%
Hypoaesthesia (reduced sense of touch or sensation): 9 people, 45.00%
Weakness: 9 people, 45.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 9 people, 45.00%
Oedema (fluid collection in tissue): 9 people, 45.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 9 people, 45.00%
Vasculitis (inflammation of a blood vessel or blood vessels): 2 people, 10.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.00%
Hypersensitivity: 1 person, 5.00%
Herpes Virus Infection: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%
Atrophic Vulvovaginitis (inflammation of the vulva): 1 person, 5.00%
Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Estrogel and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrogel:

Estrogel (2,922 reports)

Fluid retention treatments and more:

Fluid retention (79,661 reports)

Browse all side effects of Estrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,698 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,449 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrogel) and Estrogel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.