Estrogel and Upper limb fracture - a phase IV clinical study of FDA data

Summary:

Upper limb fracture is reported as a side effect among people who take Estrogel (estradiol), especially for people who are female, 60+ old, also take Metformin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Upper limb fracture when taking Estrogel. It is created by eHealthMe based on reports of 2,659 people who have side effects when taking Estrogel from the FDA, and is updated regularly.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,922 Estrogel users. Check the latest studies of Estrogel.

What is Upper limb fracture?

Upper limb fracture is found to be associated with 1,132 drugs and 1,075 conditions by eHealthMe. Check the latest studies of Upper limb fracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

2,659 people reported to have side effects when taking Estrogel.
Among them, 20 people (0.75%) have Upper limb fracture.

$Could Estrogel cause Upper limb fracture?$

Among these 20 people:

What is the gender of people who have Upper limb fracture when taking Estrogel? *

female: 100 %
male: 0.0 %

What is the age of people who have Upper limb fracture when taking Estrogel? *

What are other drugs people take besides Estrogel? *

Vitamin B6: 15 people, 75.00%
Mestinon: 15 people, 75.00%
Metformin: 15 people, 75.00%
Acetaminophen: 11 people, 55.00%
Methotrexate: 11 people, 55.00%
Progesterone: 11 people, 55.00%
Methylprednisolone: 11 people, 55.00%
Clonazepam: 10 people, 50.00%
Diphenhydramine Hydrochloride: 10 people, 50.00%
Folic Acid: 10 people, 50.00%

What are other side effects people have besides Upper limb fracture? *

Fall: 19 people, 95.00%
Pain: 18 people, 90.00%
Drug Intolerance (drug sensitivity): 17 people, 85.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 17 people, 85.00%
Stress And Anxiety: 17 people, 85.00%
Drug Ineffective: 16 people, 80.00%
Wrist Fracture: 15 people, 75.00%
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 15 people, 75.00%
Malaise (a feeling of general discomfort or uneasiness): 15 people, 75.00%
Diabetes Mellitus Inadequate Control: 15 people, 75.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 16 people, 80.00%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 15 people, 75.00%
Diabetes: 15 people, 75.00%
Osteoporosis (bones weak and more likely to break): 2 people, 10.00%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 10.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Estrogel and have Upper limb fracture?

- Check whether Upper limb fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrogel:

Estrogel (2,922 reports)

Browse all side effects of Estrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Upper limb fracture:

Upper limb fracture (1,132 drugs)

Browse all the conditions that are associated with Upper limb fracture:

Upper limb fracture (1,075 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrogel) and Estrogel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.