Estropipate and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Estropipate (estropipate), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Plaquenil, and have Osteoporosis.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Estropipate. It is created by eHealthMe based on reports of 1,633 people who have side effects when taking Estropipate from the FDA, and is updated regularly.

What is Estropipate?

Estropipate has active ingredients of estropipate. It is often used in hormone replacement therapy. eHealthMe is studying from 1,659 Estropipate users. Check the latest studies of Estropipate.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,880 drugs and 2,647 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

1,633 people reported to have side effects when taking Estropipate.
Among them, 19 people (1.16%) have Osteoarthritis.

Among these 19 people:

How long have people been on Estropipate when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Estropipate? *

female: 94.12 %
male: 5.88 %

What is the age of people who have Osteoarthritis when taking Estropipate? *

What are other drugs people take besides Estropipate? *

What are other side effects people have besides Osteoarthritis? *

Femur Fracture: 8 people, 42.11%
Osteoporosis (bones weak and more likely to break): 6 people, 31.58%
Joint Pain: 6 people, 31.58%
Rickets (softening of bones): 6 people, 31.58%
Dizziness: 6 people, 31.58%
Arthropathy: 5 people, 26.32%
Meniscus Lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia): 5 people, 26.32%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 5 people, 26.32%
Patellofemoral Pain Syndrome (pain in the front of the knee): 5 people, 26.32%
Ligament Disorder (disease of ligament): 5 people, 26.32%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 36.84%
High Blood Cholesterol: 5 people, 26.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 26.32%
Dry Eyes (lack of adequate tears): 3 people, 15.79%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 15.79%
Rashes (redness): 3 people, 15.79%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 15.79%
Hot Flush (sudden feelings of heat): 3 people, 15.79%
Dry Mouth: 3 people, 15.79%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Estropipate and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estropipate:

Estropipate (1,659 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,655 reports)

Browse all side effects of Estropipate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,880 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,647 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estropipate (the active ingredients of Estropipate) and Estropipate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.