Excedrin and Post traumatic stress disorder - a phase IV clinical study of FDA data

Summary:

Post traumatic stress disorder is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 40-49 old, also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Post traumatic stress disorder when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Post traumatic stress disorder?

Post traumatic stress disorder is found to be associated with 822 drugs and 912 conditions by eHealthMe. Check the latest studies of Post traumatic stress disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 39 people (0.18%) have Post traumatic stress disorder.

Could Excedrin cause Post traumatic stress disorder?

Among these 39 people:

What is the gender of people who have Post traumatic stress disorder when taking Excedrin? *

female: 94.87 %
male: 5.13 %

What is the age of people who have Post traumatic stress disorder when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Post traumatic stress disorder? *

Stress And Anxiety: 21 people, 53.85%
Abdominal Discomfort: 15 people, 38.46%
Panic Disorder: 12 people, 30.77%
Fibromyalgia (a long-term condition which causes pain all over the body): 12 people, 30.77%
Mood Swings (an extreme or rapid change in mood): 9 people, 23.08%
Fatigue (feeling of tiredness): 8 people, 20.51%
Dissociation: 7 people, 17.95%
Dizziness: 7 people, 17.95%
Muscle Twitching: 7 people, 17.95%
Affect Lability (emotional incontinence): 7 people, 17.95%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 18 people, 46.15%
Depression: 10 people, 25.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 25.64%
Nausea (feeling of having an urge to vomit): 7 people, 17.95%
High Blood Pressure: 5 people, 12.82%
Muscle Spasms (muscle contraction): 4 people, 10.26%
Blood Potassium Decreased: 4 people, 10.26%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 10.26%
Stress And Anxiety: 4 people, 10.26%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Post traumatic stress disorder?

- Check whether Post traumatic stress disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Post traumatic stress disorder treatments and more:

Post traumatic stress disorder (20,331 reports)

How severe was Post traumatic stress disorder and when was it recovered:

Post traumatic stress disorder in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Post traumatic stress disorder and drugs with ingredients of acetaminophen; aspirin; caffeine (39 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Post traumatic stress disorder:

Post traumatic stress disorder (822 drugs)

Browse all the conditions that are associated with Post traumatic stress disorder:

Post traumatic stress disorder (912 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.