Exforge and Ra - a phase IV clinical study of FDA data

Summary:

Ra is reported as a side effect among people who take Exforge (amlodipine besylate; valsartan), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Enbrel, and have Osteoporosis.

The phase IV clinical study analyzes which people have Ra when taking Exforge. It is created by eHealthMe based on reports of 12,942 people who have side effects when taking Exforge from the FDA, and is updated regularly.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

What is Ra?

Ra (rheumatoid arthritis) is found to be associated with 1,611 drugs and 2,107 conditions by eHealthMe. Check the latest studies of Ra.

On Apr, 16, 2026

12,942 people reported to have side effects when taking Exforge.
Among them, 38 people (0.29%) have Ra.

Among these 38 people:

How long have people been on Exforge when they have Ra? *

What is the gender of people who have Ra when taking Exforge? *

female: 70.27 %
male: 29.73 %

What is the age of people who have Ra when taking Exforge? *

What are other drugs people take besides Exforge? *

What are other side effects people have besides Ra? *

Pain: 7 people, 18.42%
Joint Pain: 6 people, 15.79%
Depression: 6 people, 15.79%
Acute Kidney Failure: 5 people, 13.16%
Feeling Abnormal: 5 people, 13.16%
Blood Creatinine Increased: 4 people, 10.53%
Dyspnea (difficult or laboured breathing): 4 people, 10.53%
Drug Ineffective: 4 people, 10.53%
Fatigue (feeling of tiredness): 4 people, 10.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.53%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 5 people, 13.16%
Pain: 4 people, 10.53%
Indigestion: 3 people, 7.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.89%
High Blood Cholesterol: 3 people, 7.89%
Cardiac Failure: 2 people, 5.26%
Diabetes: 2 people, 5.26%
Pulmonary Sarcoidosis (growth of tiny collections of inflammatory cells in lungs): 1 person, 2.63%
Hot Flush (sudden feelings of heat): 1 person, 2.63%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 1 person, 2.63%

* Approximation only. Some reports may have incomplete information.

Do you take Exforge and have Ra?

- Check whether Ra is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Exforge:

Exforge (13,350 reports)

Ra treatments and more:

Ra (1,091,830 reports)

How severe was Ra and when was it recovered:

Ra in Exforge

Expand to all the drugs that have ingredients of amlodipine besylate; valsartan:

Ra and drugs with ingredients of amlodipine besylate; valsartan (26 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Exforge:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ra:

Ra (1,611 drugs)

Browse all the conditions that are associated with Ra:

Ra (2,107 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; valsartan (the active ingredients of Exforge) and Exforge (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.