Exforge and Spinal compression fracture - a phase IV clinical study of FDA data

Summary:

Spinal compression fracture is reported as a side effect among people who take Exforge (amlodipine besylate; valsartan), especially for people who are female, 60+ old, also take Nexium, and have Osteoporosis.

The phase IV clinical study analyzes which people have Spinal compression fracture when taking Exforge. It is created by eHealthMe based on reports of 12,942 people who have side effects when taking Exforge from the FDA, and is updated regularly.

What is Exforge?

Exforge has active ingredients of amlodipine besylate; valsartan. It is often used in high blood pressure. eHealthMe is studying from 13,350 Exforge users. Check the latest studies of Exforge.

What is Spinal compression fracture?

Spinal compression fracture (fracture due to spinal compression on bone) is found to be associated with 1,088 drugs and 904 conditions by eHealthMe. Check the latest studies of Spinal compression fracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

12,942 people reported to have side effects when taking Exforge.
Among them, 14 people (0.11%) have Spinal compression fracture.

$Could Exforge cause Spinal compression fracture?$

Among these 14 people:

What is the gender of people who have Spinal compression fracture when taking Exforge? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Spinal compression fracture when taking Exforge? *

What are other drugs people take besides Exforge? *

What are other side effects people have besides Spinal compression fracture? *

Back Pain: 7 people, 50.00%
Fall: 5 people, 35.71%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 28.57%
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 4 people, 28.57%
Insomnia (sleeplessness): 3 people, 21.43%
Breast Pain: 3 people, 21.43%
Cough: 3 people, 21.43%
Weakness: 3 people, 21.43%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 21.43%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 21.43%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 4 people, 28.57%
Diabetes: 3 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 7.14%
Blood Testosterone Decreased: 1 person, 7.14%
Bone Pain: 1 person, 7.14%
Cardiac Disorder: 1 person, 7.14%
Constipation: 1 person, 7.14%
Depression: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Exforge and have Spinal compression fracture?

- Check whether Spinal compression fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Exforge:

Exforge (13,350 reports)

Spinal compression fracture treatments and more:

Spinal compression fracture (13,743 reports)

How severe was Spinal compression fracture and when was it recovered:

Spinal compression fracture in Exforge

Expand to all the drugs that have ingredients of amlodipine besylate; valsartan:

Spinal compression fracture and drugs with ingredients of amlodipine besylate; valsartan (14 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Exforge:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal compression fracture:

Spinal compression fracture (1,088 drugs)

Browse all the conditions that are associated with Spinal compression fracture:

Spinal compression fracture (904 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; valsartan (the active ingredients of Exforge) and Exforge (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.