Exparel and Intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Intestinal obstruction is reported as a side effect among people who take Exparel (bupivacaine), especially for people who are female, also take Acetaminophen, and have Nerve block.

The phase IV clinical study analyzes which people have Intestinal obstruction when taking Exparel. It is created by eHealthMe based on reports of 1,880 people who have side effects when taking Exparel from the FDA, and is updated regularly.

What is Exparel?

Exparel has active ingredients of bupivacaine. eHealthMe is studying from 1,881 Exparel users. Check the latest studies of Exparel.

What is Intestinal obstruction?

Intestinal obstruction is found to be associated with 1,884 drugs and 2,619 conditions by eHealthMe. Check the latest studies of Intestinal obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

1,880 people reported to have side effects when taking Exparel.
Among them, 17 people (0.9%) have Intestinal obstruction.

Could Exparel cause Intestinal obstruction?

Among these 17 people:

What is the gender of people who have Intestinal obstruction when taking Exparel? *

female: 100 %
male: 0.0 %

What are other drugs people take besides Exparel? *

What are other side effects people have besides Intestinal obstruction? *

Hospitalisation: 6 people, 35.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 35.29%
Urinary Retention (the inability to completely or partially empty the bladder): 5 people, 29.41%
Pneumonia: 4 people, 23.53%
Pain: 3 people, 17.65%
Post Procedural Complication: 3 people, 17.65%
Pulmonary Air Leakage: 3 people, 17.65%
Procedural Nausea: 2 people, 11.76%
Dizziness: 2 people, 11.76%
Postoperative Wound Infection: 2 people, 11.76%

What are the existing conditions these people have? *

Nerve Block (the interruption of signals travelling along a nerve): 5 people, 29.41%
Procedural Pain: 2 people, 11.76%
Pain: 2 people, 11.76%
Metastases To Pleura (cancer spreads to pleura): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Exparel and have Intestinal obstruction?

- Check whether Intestinal obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Exparel:

Exparel (1,881 reports)

Browse all side effects of Exparel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal obstruction:

Intestinal obstruction (1,884 drugs)

Browse all the conditions that are associated with Intestinal obstruction:

Intestinal obstruction (2,619 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupivacaine (the active ingredients of Exparel) and Exparel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.