Famotidine and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Famotidine (famotidine), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Vitamin D3, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Famotidine. It is created by eHealthMe based on reports of 81,914 people who have side effects when taking Famotidine from the FDA, and is updated regularly.

What is Famotidine?

Famotidine has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 83,423 Famotidine users. Check the latest studies of Famotidine.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 948 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

81,914 people reported to have side effects when taking Famotidine.
Among them, 100 people (0.12%) have Knee joint replacement.

Could Famotidine cause Knee joint replacement?

Among these 100 people:

How long have people been on Famotidine when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Famotidine? *

female: 75 %
male: 25 %

What is the age of people who have Knee joint replacement when taking Famotidine? *

What are other drugs people take besides Famotidine? *

What are other side effects people have besides Knee joint replacement? *

Pain: 15 people, 15.00%
Urinary Tract Infection: 14 people, 14.00%
Joint Pain: 12 people, 12.00%
Back Pain: 10 people, 10.00%
Headache (pain in head): 9 people, 9.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 9.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 9 people, 9.00%
Rashes (redness): 9 people, 9.00%
Weight Decreased: 8 people, 8.00%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 8.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 19 people, 19.00%
High Blood Pressure: 11 people, 11.00%
High Blood Cholesterol: 10 people, 10.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 9.00%
Immunodeficiency Common Variable: 8 people, 8.00%
Pain: 5 people, 5.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 4.00%
Plasmacytoma (neoplasm of plasma cells (usually in bone marrow)): 4 people, 4.00%
Depression: 4 people, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Famotidine and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Famotidine:

Famotidine (83,423 reports)

Browse all side effects of Famotidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (948 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Famotidine) and Famotidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.