Febuxostat and International normalised ratio increased - a phase IV clinical study of FDA data

Summary:

International normalised ratio increased is reported as a side effect among people who take Febuxostat (febuxostat), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Furosemide, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have International normalised ratio increased when taking Febuxostat. It is created by eHealthMe based on reports of 9,653 people who have side effects when taking Febuxostat from the FDA, and is updated regularly.

What is Febuxostat?

Febuxostat has active ingredients of febuxostat. eHealthMe is studying from 9,693 Febuxostat users. Check the latest studies of Febuxostat.

What is International normalised ratio increased?

International normalised ratio increased is found to be associated with 1,333 drugs and 1,727 conditions by eHealthMe. Check the latest studies of International normalised ratio increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

9,653 people reported to have side effects when taking Febuxostat.
Among them, 41 people (0.42%) have International normalised ratio increased.

Could Febuxostat cause International normalised ratio increased?

Among these 41 people:

How long have people been on Febuxostat when they have International normalised ratio increased? *

What is the gender of people who have International normalised ratio increased when taking Febuxostat? *

female: 28.57 %
male: 71.43 %

What is the age of people who have International normalised ratio increased when taking Febuxostat? *

What are other drugs people take besides Febuxostat? *

What are other side effects people have besides International normalised ratio increased? *

Thrombocytopenia (decrease of platelets in blood): 10 people, 24.39%
Anaemia (lack of blood): 9 people, 21.95%
Blood Lactate Dehydrogenase Increased: 9 people, 21.95%
Head Injury: 8 people, 19.51%
Weakness: 6 people, 14.63%
Dyspnea (difficult or laboured breathing): 6 people, 14.63%
Shock Haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding): 6 people, 14.63%
Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 12.20%
Necrotising Fasciitis (an uncommon life-threatening soft-tissue infection): 5 people, 12.20%
Haemarthrosis (haemarthrosis is where blood is able to enter the joint capsule): 5 people, 12.20%

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 15 people, 36.59%
High Blood Pressure: 9 people, 21.95%
Thrombophlebitis (swelling (inflammation) of a vein caused by a blood clot): 6 people, 14.63%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 12.20%
Chronic Kidney Disease: 5 people, 12.20%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 12.20%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 7.32%
Gout (uric acid crystals building up in the body): 3 people, 7.32%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 4.88%
Percutaneous Coronary Intervention: 2 people, 4.88%

* Approximation only. Some reports may have incomplete information.

Do you take Febuxostat and have International normalised ratio increased?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Febuxostat:

Febuxostat (9,693 reports)

International normalised ratio increased treatments and more:

International normalised ratio increased (40,071 reports)

How severe was International normalised ratio increased and when was it recovered:

International normalised ratio increased in Febuxostat

Expand to all the drugs that have ingredients of febuxostat:

International normalised ratio increased and drugs with ingredients of febuxostat

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Febuxostat:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with International normalised ratio increased:

International normalised ratio increased (1,333 drugs)

Browse all the conditions that are associated with International normalised ratio increased:

International normalised ratio increased (1,727 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on febuxostat (the active ingredients of Febuxostat) and Febuxostat (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.