Prometrium and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Zanaflex (tizanidine hydrochloride). Common drug interactions include hypertension among females.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Zanaflex. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

37 people who take Prometrium and Zanaflex together, and have interactions are studied.

Prometrium and Zanaflex drug interactions.

What are the common drug interactions of Prometrium and Zanaflex, by gender? *:

female:

Hypertension (high blood pressure)
Fall
Bacteraemia (presence of bacteria in the blood)
Bone disorder
Bone erosion
Bone fragmentation
Cardiac failure congestive
Constipation
Cough
Deformity (disfigurement)

male:

n/a

What are the common drug interactions of Prometrium and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Parathyroid disorder
Renal failure chronic (long lasting kidney dysfunction)
Vaginal fistula (fistula or abnormal connection between the rectum and the vagina)

30-39:

Migraine (headache)
Abasia (inability to walk)
Hypertension (high blood pressure)
Influenza like illness
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Moaning (a low, sustained, mournful cry)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Muscle tightness
Tremor (trembling or shaking movements in one or more parts of your body)

40-49:

Oedema peripheral (superficial swelling)
Abdominal pain
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Bacteraemia (presence of bacteria in the blood)
Blood cholesterol increased

50-59:

Exostosis (formation of new bone on the surface of a bone)
Skin fibrosis (fibrous tissue formation on skin)
Cardiomyopathy (weakening of the heart muscle)
Ejection fraction decreased (systolic heart failure)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Abdominal pain
Anxiety
Cough
Fall
Nausea (feeling of having an urge to vomit)

60+:

Adrenocortical insufficiency chronic (hormonal-disorder that occurs when the adrenal glands do not produce enough of certain hormones-chronic adrenocortical disorder)
Dehydration (dryness resulting from the removal of water)
Polymyalgia (pain in many muscles)
Poor venous access
Pulse absent
Recurrent cancer (repeated cancer)
White blood cell count increased
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 48.65%
High Blood Pressure: 18 people, 48.65%
Multiple Myeloma (cancer of the plasma cells): 16 people, 43.24%
Fatigue (feeling of tiredness): 16 people, 43.24%
Pain: 8 people, 21.62%
Bipolar Disorder (mood disorder): 5 people, 13.51%
Stress And Anxiety: 4 people, 10.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.81%
High Blood Cholesterol: 4 people, 10.81%
Migraine (headache): 4 people, 10.81%

* Approximation only. Some reports may have incomplete information.

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