Fenofibrate and Major depressive disorder - a phase IV clinical study of FDA data

Summary:

Major depressive disorder is reported as a side effect among people who take Fenofibrate (fenofibrate), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Mirtazapine, and have Depression.

The phase IV clinical study analyzes which people have Major depressive disorder when taking Fenofibrate. It is created by eHealthMe based on reports of 39,402 people who have side effects when taking Fenofibrate from the FDA, and is updated regularly.

What is Fenofibrate?

Fenofibrate has active ingredients of fenofibrate. It is often used in high blood cholesterol. eHealthMe is studying from 40,456 Fenofibrate users. Check the latest studies of Fenofibrate.

What is Major depressive disorder?

Major depressive disorder (a condition characterized by a long-lasting depressed mood or marked loss of interest or pleasure) is found to be associated with 1,046 drugs and 1,475 conditions by eHealthMe. Check the latest studies of Major depressive disorder.

On Apr, 21, 2026

39,402 people reported to have side effects when taking Fenofibrate.
Among them, 24 people (0.06%) have Major depressive disorder.

Could Fenofibrate cause Major depressive disorder?

Among these 24 people:

How long have people been on Fenofibrate when they have Major depressive disorder? *

What is the gender of people who have Major depressive disorder when taking Fenofibrate? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Major depressive disorder when taking Fenofibrate? *

What are other drugs people take besides Fenofibrate? *

What are other side effects people have besides Major depressive disorder? *

Stress And Anxiety: 6 people, 25.00%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 6 people, 25.00%
Cytolytic Hepatitis (dissolution or destruction of a liver cell): 6 people, 25.00%
Emotional Distress: 4 people, 16.67%
Pain: 4 people, 16.67%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 12.50%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 12.50%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 3 people, 12.50%
Osteoporosis (bones weak and more likely to break): 3 people, 12.50%
Essential Hypertension (primary hypertension): 3 people, 12.50%

What are the existing conditions these people have? *

Depression: 6 people, 25.00%
High Blood Pressure: 5 people, 20.83%
Hiv Infection: 4 people, 16.67%
Depressive Symptom: 4 people, 16.67%
Muscle Spasms (muscle contraction): 3 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 12.50%
Dyslipidaemia (abnormal amount of lipids): 3 people, 12.50%
Stress And Anxiety: 3 people, 12.50%
Muscle Aches (muscle pain): 3 people, 12.50%
Drowsiness: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Fenofibrate and have Major depressive disorder?

- Check whether Major depressive disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fenofibrate:

Fenofibrate (40,456 reports)

Browse all side effects of Fenofibrate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depressive disorder:

Major depressive disorder (1,046 drugs)

Browse all the conditions that are associated with Major depressive disorder:

Major depressive disorder (1,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fenofibrate (the active ingredients of Fenofibrate) and Fenofibrate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.