Fioricet and Eyelid ptosis - a phase IV clinical study of FDA data

Summary:

Eyelid ptosis is reported as a side effect among people who take Fioricet (acetaminophen; butalbital; caffeine), especially for people who are female, 60+ old, also take Gabapentin, and have Depression.

The phase IV clinical study analyzes which people have Eyelid ptosis when taking Fioricet. It is created by eHealthMe based on reports of 11,479 people who have side effects when taking Fioricet from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Eyelid ptosis?

Eyelid ptosis (falling of the upper or lower eyelid) is found to be associated with 708 drugs and 1,038 conditions by eHealthMe. Check the latest studies of Eyelid ptosis.

On Jul, 17, 2026

11,479 people reported to have side effects when taking Fioricet.
Among them, 26 people (0.23%) have Eyelid ptosis.

Among these 26 people:

What is the gender of people who have Eyelid ptosis when taking Fioricet? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Eyelid ptosis when taking Fioricet? *

What are other drugs people take besides Fioricet? *

What are other side effects people have besides Eyelid ptosis? *

Dizziness: 13 people, 50.00%
Dyspnea (difficult or laboured breathing): 13 people, 50.00%
Pain In Jaw: 12 people, 46.15%
Pain: 11 people, 42.31%
Pain In Extremity: 11 people, 42.31%
Atelectasis (partial or complete collapse of the lung): 11 people, 42.31%
Back Pain: 11 people, 42.31%
Nausea (feeling of having an urge to vomit): 11 people, 42.31%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 11 people, 42.31%
Swallowing Difficulty: 11 people, 42.31%

What are the existing conditions these people have? *

Depression: 10 people, 38.46%
Oral Pain: 9 people, 34.62%
Oedema (fluid collection in tissue): 9 people, 34.62%
Nausea (feeling of having an urge to vomit): 9 people, 34.62%
Multiple Myeloma (cancer of the plasma cells): 9 people, 34.62%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 4 people, 15.38%
Cough: 4 people, 15.38%
Skin Wrinkling (wrinkle on skin): 2 people, 7.69%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 7.69%
Neuropathy Peripheral (surface nerve damage): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and have Eyelid ptosis?

- Check whether Eyelid ptosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fioricet:

Fioricet (12,423 reports)

Eyelid ptosis treatments and more:

Eyelid ptosis (12,240 reports)

How severe was Eyelid ptosis and when was it recovered:

Eyelid ptosis in Fioricet

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Eyelid ptosis and drugs with ingredients of acetaminophen; butalbital; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eyelid ptosis:

Eyelid ptosis (708 drugs)

Browse all the conditions that are associated with Eyelid ptosis:

Eyelid ptosis (1,038 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Fioricet) and Fioricet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.