Flexeril and Acute myeloid leukaemia - a phase IV clinical study of FDA data

Summary:

Acute myeloid leukaemia is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are male, 60+ old, also take Prilosec, and have Nausea.

The phase IV clinical study analyzes which people have Acute myeloid leukaemia when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Acute myeloid leukaemia?

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts) is found to be associated with 721 drugs and 1,221 conditions by eHealthMe. Check the latest studies of Acute myeloid leukaemia.

On Jul, 16, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 17 people (0.05%) have Acute myeloid leukaemia.

Could Flexeril cause Acute myeloid leukaemia?

Among these 17 people:

What is the gender of people who have Acute myeloid leukaemia when taking Flexeril? *

female: 41.18 %
male: 58.82 %

What is the age of people who have Acute myeloid leukaemia when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides Acute myeloid leukaemia? *

Haematemesis (vomiting of blood): 5 people, 29.41%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 23.53%
Nausea (feeling of having an urge to vomit): 4 people, 23.53%
Thrombocytopenia (decrease of platelets in blood): 3 people, 17.65%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 17.65%
Nosebleed (bleeding from nose): 3 people, 17.65%
Fever: 3 people, 17.65%
Malignant Neoplasm Progression (cancer tumour came back): 3 people, 17.65%
Nausea And Vomiting: 3 people, 17.65%
Haemoglobin Decreased: 3 people, 17.65%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 23.53%
Pain: 3 people, 17.65%
Cough: 2 people, 11.76%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 2 people, 11.76%
Urinary Tract Infection: 1 person, 5.88%
Enlarged Prostate: 1 person, 5.88%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 5.88%
Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 5.88%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.88%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Acute myeloid leukaemia?

- Check whether Acute myeloid leukaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,308 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute myeloid leukaemia:

Acute myeloid leukaemia (721 drugs)

Browse all the conditions that are associated with Acute myeloid leukaemia:

Acute myeloid leukaemia (1,221 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.