Flexeril and Device related infection - a phase IV clinical study of FDA data

Summary:

Device related infection is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 60+ old, also take Aredia, and have Metastases to bone.

The phase IV clinical study analyzes which people have Device related infection when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Device related infection?

Device related infection is found to be associated with 1,086 drugs and 1,040 conditions by eHealthMe. Check the latest studies of Device related infection.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 85 people (0.24%) have Device related infection.

Could Flexeril cause Device related infection?

Among these 85 people:

What is the gender of people who have Device related infection when taking Flexeril? *

female: 79.27 %
male: 20.73 %

What is the age of people who have Device related infection when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides Device related infection? *

Joint Pain: 47 people, 55.29%
Fatigue (feeling of tiredness): 42 people, 49.41%
Osteonecrosis Of Jaw (death of bone of jaw): 41 people, 48.24%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 37 people, 43.53%
Weight Decreased: 34 people, 40.00%
Anaemia (lack of blood): 34 people, 40.00%
Dyspnea (difficult or laboured breathing): 34 people, 40.00%
Osteomyelitis (infection of bone): 32 people, 37.65%
Nausea (feeling of having an urge to vomit): 32 people, 37.65%
Night Sweats (sweating in night): 31 people, 36.47%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 18 people, 21.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 15.29%
Stress And Anxiety: 11 people, 12.94%
Depression: 6 people, 7.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 4.71%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 4.71%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 4.71%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 4.71%
Pain: 4 people, 4.71%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Device related infection?

- Check whether Device related infection is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,308 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Device related infection:

Device related infection (1,086 drugs)

Browse all the conditions that are associated with Device related infection:

Device related infection (1,040 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.