Flexeril and Excessive granulation tissue - a phase IV clinical study of FDA data

Summary:

Excessive granulation tissue is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are male, 60+ old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Excessive granulation tissue when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Excessive granulation tissue?

Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury) is found to be associated with 401 drugs and 286 conditions by eHealthMe. Check the latest studies of Excessive granulation tissue.

On Jun, 10, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 24 people (0.07%) have Excessive granulation tissue.

Could Flexeril cause Excessive granulation tissue?

Among these 24 people:

What is the gender of people who have Excessive granulation tissue when taking Flexeril? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Excessive granulation tissue when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides Excessive granulation tissue? *

Osteomyelitis (infection of bone): 24 people, 100.00%
Osteonecrosis Of Jaw (death of bone of jaw): 23 people, 95.83%
Neuropathy Peripheral (surface nerve damage): 22 people, 91.67%
Pain In Jaw: 21 people, 87.50%
Intervertebral Disc Degeneration (spinal disc degeneration): 19 people, 79.17%
Stress And Anxiety: 18 people, 75.00%
Swelling: 17 people, 70.83%
Hypoaesthesia (reduced sense of touch or sensation): 17 people, 70.83%
Infection: 17 people, 70.83%
Osteoporosis (bones weak and more likely to break): 17 people, 70.83%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 14 people, 58.33%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 12.50%
High Blood Cholesterol: 1 person, 4.17%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Excessive granulation tissue?

- Check whether Excessive granulation tissue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,308 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Excessive granulation tissue:

Excessive granulation tissue (401 drugs)

Browse all the conditions that are associated with Excessive granulation tissue:

Excessive granulation tissue (286 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.