Flexeril and High density lipoprotein decreased - a phase IV clinical study of FDA data

Summary:

High density lipoprotein decreased is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 40-49 old, also take Neurontin, and have Stress and anxiety.

The phase IV clinical study analyzes which people have High density lipoprotein decreased when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is High density lipoprotein decreased?

High density lipoprotein decreased is found to be associated with 482 drugs and 625 conditions by eHealthMe. Check the latest studies of High density lipoprotein decreased.

On Aug, 04, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 16 people (0.05%) have High density lipoprotein decreased.

Could Flexeril cause High density lipoprotein decreased?

Among these 16 people:

What is the gender of people who have High density lipoprotein decreased when taking Flexeril? *

female: 81.25 %
male: 18.75 %

What is the age of people who have High density lipoprotein decreased when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides High density lipoprotein decreased? *

Depression: 11 people, 68.75%
Stress And Anxiety: 9 people, 56.25%
Hypoaesthesia (reduced sense of touch or sensation): 6 people, 37.50%
Low Density Lipoprotein Increased (cholesterol increased in blood): 6 people, 37.50%
High Blood Cholesterol: 6 people, 37.50%
Constipation: 5 people, 31.25%
Diarrhea: 5 people, 31.25%
Fatigue (feeling of tiredness): 5 people, 31.25%
Gait Disturbance: 5 people, 31.25%
Pain: 5 people, 31.25%

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 43.75%
High Blood Cholesterol: 6 people, 37.50%
Depression: 5 people, 31.25%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 25.00%
High Blood Pressure: 3 people, 18.75%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 12.50%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
Joint Pain: 1 person, 6.25%
Intervertebral Disc Protrusion (spinal disc protrusion): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have High density lipoprotein decreased?

- Check whether High density lipoprotein decreased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,308 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with High density lipoprotein decreased:

High density lipoprotein decreased (482 drugs)

Browse all the conditions that are associated with High density lipoprotein decreased:

High density lipoprotein decreased (625 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.