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Flexeril and Hyperaesthesia - a phase IV clinical study of FDA data

Summary:

Hyperaesthesia is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 50-59 old, also take Lyrica, and have Pain.

The phase IV clinical study analyzes which people have Hyperaesthesia when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,306 Flexeril users. Check the latest studies of Flexeril.

What is Hyperaesthesia?

Hyperaesthesia is found to be associated with 911 drugs and 909 conditions by eHealthMe. Check the latest studies of Hyperaesthesia.

On Jan, 27, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 47 people (0.14%) have Hyperaesthesia.

Could Flexeril cause Hyperaesthesia?

Among these 47 people:

What is the gender of people who have Hyperaesthesia when taking Flexeril? *

  • female: 76.74 %
  • male: 23.26 %

What is the age of people who have Hyperaesthesia when taking Flexeril? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 5.13 %
  • 20-29: 5.13 %
  • 30-39: 12.82 %
  • 40-49: 25.64 %
  • 50-59: 35.9 %
  • 60+: 15.38 %

What are other drugs people take besides Flexeril? *

  1. Lyrica: 14 people, 29.79%
  2. Voltaren: 12 people, 25.53%
  3. Cymbalta: 11 people, 23.40%
  4. Valium: 10 people, 21.28%
  5. Vioxx: 8 people, 17.02%
  6. Lasix: 8 people, 17.02%
  7. Humira: 8 people, 17.02%
  8. Prevacid: 7 people, 14.89%
  9. Norco: 7 people, 14.89%
  10. Tylenol: 7 people, 14.89%

What are other side effects people have besides Hyperaesthesia? *

  1. Joint Pain: 22 people, 46.81%
  2. Pain: 21 people, 44.68%
  3. Fatigue (feeling of tiredness): 16 people, 34.04%
  4. Dizziness: 13 people, 27.66%
  5. Pain In Extremity: 12 people, 25.53%
  6. Neck Pain: 10 people, 21.28%
  7. Stress And Anxiety: 10 people, 21.28%
  8. Weakness: 10 people, 21.28%
  9. Headache (pain in head): 9 people, 19.15%
  10. High Blood Pressure: 9 people, 19.15%

What are the existing conditions these people have? *

  1. Pain: 16 people, 34.04%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 6 people, 12.77%
  3. Stress And Anxiety: 4 people, 8.51%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 8.51%
  5. Joint Pain: 3 people, 6.38%
  6. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 6.38%
  7. Constipation: 3 people, 6.38%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.38%
  9. Migraine (headache): 3 people, 6.38%
  10. Pain In Extremity: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Hyperaesthesia?

- Check whether Hyperaesthesia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Hyperaesthesia treatments and more:

How severe was Hyperaesthesia and when was it recovered:

Expand to all the drugs that have ingredients of cyclobenzaprine hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperaesthesia:

Browse all the conditions that are associated with Hyperaesthesia:

Drugs similar to Flexeril and Hyperaesthesia :

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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