Flexeril and Hypercortisolism - a phase IV clinical study of FDA data

Summary:

Hypercortisolism is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 50-59 old, also take Lipitor, and have Depression.

The phase IV clinical study analyzes which people have Hypercortisolism when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,304 Flexeril users. Check the latest studies of Flexeril.

What is Hypercortisolism?

Hypercortisolism (excessive secretion of one or more steroid hormones of the adrenal cortex) is found to be associated with 854 drugs and 715 conditions by eHealthMe. Check the latest studies of Hypercortisolism.

On Oct, 20, 2025

34,789 people reported to have side effects when taking Flexeril.
Among them, 10 people (0.03%) have Hypercortisolism.

Among these 10 people:

What is the gender of people who have Hypercortisolism when taking Flexeril? *

female: 100 %
male: 0.0 %

What is the age of people who have Hypercortisolism when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides Hypercortisolism? *

Memory Loss: 4 people, 40.00%
Weight Increased: 4 people, 40.00%
Blood Pressure Abnormal: 3 people, 30.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 30.00%
Diabetes: 3 people, 30.00%
Muscle Aches (muscle pain): 3 people, 30.00%
Depression: 3 people, 30.00%
Insomnia (sleeplessness): 3 people, 30.00%
Constipation: 3 people, 30.00%
Parathyroid Disorder: 2 people, 20.00%

What are the existing conditions these people have? *

Depression: 5 people, 50.00%
Stress And Anxiety: 4 people, 40.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 40.00%
Pain: 3 people, 30.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 30.00%
High Blood Cholesterol: 3 people, 30.00%
Insomnia (sleeplessness): 2 people, 20.00%
Bipolar Disorder (mood disorder): 2 people, 20.00%
Blood Pressure Abnormal: 2 people, 20.00%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 2 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have Hypercortisolism?

- Check whether Hypercortisolism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,304 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercortisolism:

Hypercortisolism (854 drugs)

Browse all the conditions that are associated with Hypercortisolism:

Hypercortisolism (715 conditions)

Drugs similar to Flexeril and Hypercortisolism :

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.