Flexeril and Hyperphagia - a phase IV clinical study of FDA data
Summary:
Hyperphagia is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lyrica, and have Fibromyalgia.
The phase IV clinical study analyzes which people have Hyperphagia when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.
What is Flexeril?
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,305 Flexeril users. Check the latest studies of Flexeril.
What is Hyperphagia?
Hyperphagia (an abnormal appetite for food) is found to be associated with 2,286 drugs and 1,938 conditions by eHealthMe. Check the latest studies of Hyperphagia.
34,789 people reported to have side effects when taking Flexeril.
Among them, 121 people (0.35%) have Hyperphagia.

Among these 121 people:
How long have people been on Flexeril when they have Hyperphagia? *
- < 1 month: 28.57 %
- 1 - 6 months: 57.14 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 14.29 %
- 2 - 5 years: 0.0 %
- 5 - 10 years: 0.0 %
- 10+ years: 0.0 %
What is the gender of people who have Hyperphagia when taking Flexeril? *
- female: 84.21 %
- male: 15.79 %
What is the age of people who have Hyperphagia when taking Flexeril? *
- 0-1: 0.0 %
- 2-9: 0.0 %
- 10-19: 2.41 %
- 20-29: 3.61 %
- 30-39: 15.66 %
- 40-49: 30.12 %
- 50-59: 18.07 %
- 60+: 30.12 %
What are other drugs people take besides Flexeril? *
- Lyrica: 26 people, 21.49%
- Cymbalta: 21 people, 17.36%
- Celebrex: 18 people, 14.88%
- Lasix: 16 people, 13.22%
- Neurontin: 16 people, 13.22%
- Xanax: 16 people, 13.22%
- Zyrtec: 15 people, 12.40%
- Klonopin: 14 people, 11.57%
- Ativan: 14 people, 11.57%
- Xyrem: 13 people, 10.74%
What are other side effects people have besides Hyperphagia? *
- Weight Increased: 48 people, 39.67%
- Nausea (feeling of having an urge to vomit): 35 people, 28.93%
- Fatigue (feeling of tiredness): 31 people, 25.62%
- Pain: 30 people, 24.79%
- Insomnia (sleeplessness): 26 people, 21.49%
- Dizziness: 26 people, 21.49%
- Stress And Anxiety: 25 people, 20.66%
- Headache (pain in head): 23 people, 19.01%
- Constipation: 19 people, 15.70%
- Weight Decreased: 18 people, 14.88%
What are the existing conditions these people have? *
- Pain: 17 people, 14.05%
- Fibromyalgia (a long-term condition which causes pain all over the body): 17 people, 14.05%
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 9.92%
- Stress And Anxiety: 11 people, 9.09%
- Sleep Disorder: 8 people, 6.61%
- Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 6.61%
- Neuropathy Peripheral (surface nerve damage): 8 people, 6.61%
- Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 6.61%
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 6.61%
- Depression: 8 people, 6.61%
* Approximation only. Some reports may have incomplete information.
Do you take Flexeril and have Hyperphagia?
- Check whether Hyperphagia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, long term effects of, and alternative drugs to Flexeril:
- Flexeril (38,305 reports)
Hyperphagia treatments and more:
- Hyperphagia (35,586 reports)
How severe was Hyperphagia and when was it recovered:
Expand to all the drugs that have ingredients of cyclobenzaprine hydrochloride:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Flexeril side effects:
- Flexeril side effect: Pain (4,282 reports)
- Flexeril side effect: Drug ineffective (2,359 reports)
Browse all side effects of Flexeril:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Hyperphagia:
- Metformin side effect: Hyperphagia (1,708 reports)
- Prednisone side effect: Hyperphagia (1,648 reports)
- Aspirin side effect: Hyperphagia (1,297 reports)
- Lyrica side effect: Hyperphagia (1,294 reports)
- Byetta side effect: Hyperphagia (1,104 reports)
- Gabapentin side effect: Hyperphagia (1,089 reports)
- Abilify side effect: Hyperphagia (1,087 reports)
- Vitamin d side effect: Hyperphagia (1,002 reports)
- Risperdal side effect: Hyperphagia (1,000 reports)
- Seroquel side effect: Hyperphagia (933 reports)
Browse all the drugs that are associated with Hyperphagia:
- Hyperphagia (2,286 drugs)
Common conditions associated with Hyperphagia:
- Diabetic type 2: 2,272 reports
- Depression: 1,879 reports
- Antidepressant therapy: 1,878 reports
- Rheumatoid arthritis: 1,146 reports
- Anxiety aggravated: 1,066 reports
- Htn: 1,065 reports
- Diabetes mellitus: 1,039 reports
- Diabetes: 1,034 reports
- Dm: 1,031 reports
- Bipolar disorder: 951 reports
Browse all the conditions that are associated with Hyperphagia:
- Hyperphagia (1,938 conditions)
Drugs similar to Flexeril and Hyperphagia :
How the study uses the data?
The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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