Flexeril and Reflux - a phase IV clinical study of FDA data
Summary:
Reflux is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Nexium, and have Pain.
The phase IV clinical study analyzes which people have Reflux when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.
What is Flexeril?
Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,304 Flexeril users. Check the latest studies of Flexeril.
What is Reflux?
Reflux (stomach contents come back up into the food pipe (gullet or oesophagus) or even into the mouth) is found to be associated with 2,593 drugs and 3,444 conditions by eHealthMe. Check the latest studies of Reflux.
34,789 people reported to have side effects when taking Flexeril.
Among them, 989 people (2.84%) have Reflux.

Among these 989 people:
How long have people been on Flexeril when they have Reflux? *
- < 1 month: 36.36 %
- 1 - 6 months: 18.18 %
- 6 - 12 months: 0.0 %
- 1 - 2 years: 3.03 %
- 2 - 5 years: 24.24 %
- 5 - 10 years: 6.06 %
- 10+ years: 12.12 %
What is the gender of people who have Reflux when taking Flexeril? *
- female: 72.89 %
- male: 27.11 %
What is the age of people who have Reflux when taking Flexeril? *
- 0-1: 0.13 %
- 2-9: 0.13 %
- 10-19: 0.89 %
- 20-29: 2.29 %
- 30-39: 5.21 %
- 40-49: 25.67 %
- 50-59: 35.83 %
- 60+: 29.61 %
What are other drugs people take besides Flexeril? *
- Nexium: 267 people, 27.00%
- Prilosec: 238 people, 24.06%
- Neurontin: 226 people, 22.85%
- Zometa: 218 people, 22.04%
- Percocet: 204 people, 20.63%
- Protonix: 196 people, 19.82%
- Vioxx: 193 people, 19.51%
- Ambien: 191 people, 19.31%
- Prevacid: 183 people, 18.50%
- Lasix: 183 people, 18.50%
What are other side effects people have besides Reflux? *
- Stress And Anxiety: 366 people, 37.01%
- Pain: 327 people, 33.06%
- High Blood Pressure: 322 people, 32.56%
- Depression: 312 people, 31.55%
- Nausea (feeling of having an urge to vomit): 265 people, 26.79%
- Fatigue (feeling of tiredness): 227 people, 22.95%
- Diarrhea: 223 people, 22.55%
- Joint Pain: 207 people, 20.93%
- Dizziness: 205 people, 20.73%
- Chest Pain: 205 people, 20.73%
What are the existing conditions these people have? *
- Pain: 231 people, 23.36%
- High Blood Pressure: 128 people, 12.94%
- Stress And Anxiety: 124 people, 12.54%
- Depression: 85 people, 8.59%
- Osteoporosis (bones weak and more likely to break): 83 people, 8.39%
- High Blood Cholesterol: 78 people, 7.89%
- Multiple Myeloma (cancer of the plasma cells): 71 people, 7.18%
- Diabetes: 53 people, 5.36%
- Fibromyalgia (a long-term condition which causes pain all over the body): 43 people, 4.35%
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 42 people, 4.25%
* Approximation only. Some reports may have incomplete information.
Do you take Flexeril and have Reflux?
- Check whether Reflux is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, long term effects of, and alternative drugs to Flexeril:
- Flexeril (38,304 reports)
Reflux treatments and more:
- Reflux (445,707 reports)
How severe was Reflux and when was it recovered:
Expand to all the drugs that have ingredients of cyclobenzaprine hydrochloride:
Sub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Common Flexeril side effects:
Browse all side effects of Flexeril:
a b c d e f g h i j k l m n o p q r s t u v w x y zCommon drugs associated with Reflux:
- Nexium side effect: Reflux (12,089 reports)
- Prednisone side effect: Reflux (8,566 reports)
- Aspirin side effect: Reflux (7,706 reports)
- Omeprazole side effect: Reflux (7,184 reports)
- Fosamax side effect: Reflux (7,170 reports)
- Prilosec side effect: Reflux (7,041 reports)
- Pantoprazole side effect: Reflux (6,020 reports)
- Protonix side effect: Reflux (4,972 reports)
- Prevacid side effect: Reflux (4,931 reports)
- Lisinopril side effect: Reflux (4,561 reports)
Browse all the drugs that are associated with Reflux:
- Reflux (2,593 drugs)
Common conditions associated with Reflux:
- Hypertension aggravated: 8,809 reports
- Blood pressure increased: 8,796 reports
- Peptic esophagitis: 8,087 reports
- Heartburn: 7,618 reports
- Osteoporosis: 6,424 reports
- Thin bones: 6,141 reports
- Reflux esophagitis: 5,786 reports
- Pain: 5,547 reports
- Hypnosis and pain: 5,525 reports
- Non-cardiac chest pain: 5,263 reports
Browse all the conditions that are associated with Reflux:
- Reflux (3,444 conditions)
Drugs similar to Flexeril and Reflux :
How the study uses the data?
The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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