Flexeril and T1d - a phase IV clinical study of FDA data

Summary:

T1d is reported as a side effect among people who take Flexeril (cyclobenzaprine hydrochloride), especially for people who are female, 30-39 old, also take Seroquel, and have Depression.

The phase IV clinical study analyzes which people have T1d when taking Flexeril. It is created by eHealthMe based on reports of 34,789 people who have side effects when taking Flexeril from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,307 Flexeril users. Check the latest studies of Flexeril.

What is T1d?

T1d is found to be associated with 774 drugs and 1,639 conditions by eHealthMe. Check the latest studies of T1d.

On Jan, 28, 2026

34,789 people reported to have side effects when taking Flexeril.
Among them, 47 people (0.14%) have T1d.

Among these 47 people:

What is the gender of people who have T1d when taking Flexeril? *

female: 63.83 %
male: 36.17 %

What is the age of people who have T1d when taking Flexeril? *

What are other drugs people take besides Flexeril? *

What are other side effects people have besides T1d? *

Type 2 Diabetes: 22 people, 46.81%
Diabetes: 21 people, 44.68%
Diabetes Mellitus Inadequate Control: 17 people, 36.17%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 14 people, 29.79%
Pancreatitis (inflammation of pancreas): 13 people, 27.66%
Diabetic Ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 12 people, 25.53%
Diabetic Retinopathy (damage to the retina caused by complications of diabetes): 9 people, 19.15%
High Blood Cholesterol: 8 people, 17.02%
Dyspnea (difficult or laboured breathing): 8 people, 17.02%
Dizziness: 8 people, 17.02%

What are the existing conditions these people have? *

Depression: 26 people, 55.32%
Bipolar Disorder (mood disorder): 18 people, 38.30%
Stress And Anxiety: 16 people, 34.04%
Sleep Disorder: 16 people, 34.04%
Pain: 13 people, 27.66%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 17.02%
Insomnia (sleeplessness): 8 people, 17.02%
High Blood Cholesterol: 6 people, 12.77%
Chest Pain: 5 people, 10.64%
Diabetes: 5 people, 10.64%

* Approximation only. Some reports may have incomplete information.

Do you take Flexeril and have T1d?

- Check whether T1d is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flexeril:

Flexeril (38,307 reports)

T1d treatments and more:

T1d (46,844 reports)

Browse all side effects of Flexeril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with T1d:

T1d (774 drugs)

Browse all the conditions that are associated with T1d:

T1d (1,639 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cyclobenzaprine hydrochloride (the active ingredients of Flexeril) and Flexeril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.