Flolan and Hyperthyroidism - a phase IV clinical study of FDA data

Summary:

Hyperthyroidism is reported as a side effect among people who take Flolan (epoprostenol sodium), especially for people who are female, 30-39 old, have been taking the drug for 5 - 10 years also take Tracleer, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Hyperthyroidism when taking Flolan. It is created by eHealthMe based on reports of 10,044 people who have side effects when taking Flolan from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Hyperthyroidism?

Hyperthyroidism (over activity of the thyroid gland) is found to be associated with 1,032 drugs and 1,426 conditions by eHealthMe. Check the latest studies of Hyperthyroidism.

On Jan, 22, 2026

10,044 people reported to have side effects when taking Flolan.
Among them, 126 people (1.25%) have Hyperthyroidism.

Among these 126 people:

* Approximation only. Some reports may have incomplete information.

Do you take Flolan and have Hyperthyroidism?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flolan:

Flolan (10,067 reports)

Hyperthyroidism treatments and more:

Hyperthyroidism (26,829 reports)

How severe was Hyperthyroidism and when was it recovered:

Hyperthyroidism in Flolan

Expand to all the drugs that have ingredients of epoprostenol sodium:

Hyperthyroidism and drugs with ingredients of epoprostenol sodium (266 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Flolan side effects:

Flolan side effect: Dyspnea (difficult or laboured breathing) (1,263 reports)
Flolan side effect: Hospitalisation (707 reports)

Browse all side effects of Flolan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hyperthyroidism:

Browse all the drugs that are associated with Hyperthyroidism:

Hyperthyroidism (1,032 drugs)

Common conditions associated with Hyperthyroidism:

Atrial fibrillation: 1,072 reports
Hypothyroid: 958 reports
Hypothyroidy: 957 reports
Hypertension aggravated: 904 reports
Hbp: 900 reports
Ms hug: 693 reports
Malignant melanoma: 553 reports
Pain: 444 reports
Osteoporosis: 434 reports
Alternative medicine - pain relief: 433 reports

Browse all the conditions that are associated with Hyperthyroidism:

Hyperthyroidism (1,426 conditions)

Related publications that referenced our studies

Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .
Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on epoprostenol sodium (the active ingredients of Flolan) and Flolan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.