Flolan and Splenomegaly - a phase IV clinical study of FDA data

Summary:

Splenomegaly is reported as a side effect among people who take Flolan (epoprostenol sodium), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Tracleer, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Splenomegaly when taking Flolan. It is created by eHealthMe based on reports of 10,044 people who have side effects when taking Flolan from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Splenomegaly?

Splenomegaly (enlargement of spleen) is found to be associated with 1,104 drugs and 1,478 conditions by eHealthMe. Check the latest studies of Splenomegaly.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

10,044 people reported to have side effects when taking Flolan.
Among them, 40 people (0.4%) have Splenomegaly.

Among these 40 people:

How long have people been on Flolan when they have Splenomegaly? *

What is the gender of people who have Splenomegaly when taking Flolan? *

female: 92.5 %
male: 7.5 %

What is the age of people who have Splenomegaly when taking Flolan? *

What are other drugs people take besides Flolan? *

What are other side effects people have besides Splenomegaly? *

Thrombocytopenia (decrease of platelets in blood): 28 people, 70.00%
Ascites (accumulation of fluid in the abdominal cavity): 16 people, 40.00%
Nausea (feeling of having an urge to vomit): 13 people, 32.50%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 13 people, 32.50%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 13 people, 32.50%
Abdominal Distension: 12 people, 30.00%
Haemoglobin Decreased: 11 people, 27.50%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 9 people, 22.50%
Hepatotoxicity (chemical-driven liver damage): 9 people, 22.50%
Catheter Related Infection: 9 people, 22.50%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 30.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 30.00%
Infusion Site Pain: 6 people, 15.00%
Cardiac Failure: 6 people, 15.00%
Pulmonary Hypertension Primary (increase in blood pressure in the lung artery with no cause): 2 people, 5.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.50%

* Approximation only. Some reports may have incomplete information.

Do you take Flolan and have Splenomegaly?

- Check whether Splenomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flolan:

Flolan (10,067 reports)

Splenomegaly treatments and more:

Splenomegaly (17,257 reports)

Browse all side effects of Flolan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenomegaly:

Splenomegaly (1,104 drugs)

Browse all the conditions that are associated with Splenomegaly:

Splenomegaly (1,478 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epoprostenol sodium (the active ingredients of Flolan) and Flolan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.