Zanaflex and C-reactive protein increased - a phase IV clinical study of FDA data

Summary:

C-reactive protein increased is reported as a side effect among people who take Zanaflex (tizanidine hydrochloride), especially for people who are female, 60+ old, also take Lyrica, and have Joint pain.

The phase IV clinical study analyzes which people have C-reactive protein increased when taking Zanaflex. It is created by eHealthMe based on reports of 16,325 people who have side effects when taking Zanaflex from the FDA, and is updated regularly.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

What is C-reactive protein increased?

C-reactive protein increased is found to be associated with 1,568 drugs and 2,281 conditions by eHealthMe. Check the latest studies of C-reactive protein increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

16,325 people reported to have side effects when taking Zanaflex.
Among them, 16 people (0.1%) have C-reactive protein increased.

Could Zanaflex cause C-reactive protein increased?

Among these 16 people:

What is the gender of people who have C-reactive protein increased when taking Zanaflex? *

female: 81.25 %
male: 18.75 %

What is the age of people who have C-reactive protein increased when taking Zanaflex? *

What are other drugs people take besides Zanaflex? *

What are other side effects people have besides C-reactive protein increased? *

Weight Increased: 7 people, 43.75%
Red Blood Cell Sedimentation Rate Increased: 6 people, 37.50%
Confusional State: 5 people, 31.25%
Weight Decreased: 5 people, 31.25%
Oedema Peripheral (superficial swelling): 5 people, 31.25%
Drug Ineffective: 5 people, 31.25%
Headache (pain in head): 4 people, 25.00%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 4 people, 25.00%
Inflammation: 4 people, 25.00%
Fibrin D Dimer Increased: 4 people, 25.00%

What are the existing conditions these people have? *

Joint Pain: 5 people, 31.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 25.00%
Bladder Disorder: 3 people, 18.75%
Neuropathy Peripheral (surface nerve damage): 3 people, 18.75%
Muscle Aches (muscle pain): 3 people, 18.75%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 18.75%
Dyspnea (difficult or laboured breathing): 2 people, 12.50%
Tremor (trembling or shaking movements in one or more parts of your body): 1 person, 6.25%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Zanaflex and have C-reactive protein increased?

- Check whether C-reactive protein increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zanaflex:

Zanaflex (17,476 reports)

Browse all side effects of Zanaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C-reactive protein increased:

C-reactive protein increased (1,568 drugs)

Browse all the conditions that are associated with C-reactive protein increased:

C-reactive protein increased (2,281 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tizanidine hydrochloride (the active ingredients of Zanaflex) and Zanaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.