Fluconazole and Adrenal suppression - a phase IV clinical study of FDA data

Summary:

Adrenal suppression is reported as a side effect among people who take Fluconazole (fluconazole), especially for people who are male, 50-59 old, also take Darunavir, and have Oral candidiasis.

The phase IV clinical study analyzes which people have Adrenal suppression when taking Fluconazole. It is created by eHealthMe based on reports of 69,269 people who have side effects when taking Fluconazole from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Adrenal suppression?

Adrenal suppression (suppression of cortisol secretion by the adrenal glands) is found to be associated with 118 drugs and 220 conditions by eHealthMe. Check the latest studies of Adrenal suppression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

69,269 people reported to have side effects when taking Fluconazole.
Among them, 23 people (0.03%) have Adrenal suppression.

Could Fluconazole cause Adrenal suppression?

Among these 23 people:

What is the gender of people who have Adrenal suppression when taking Fluconazole? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Adrenal suppression when taking Fluconazole? *

What are other drugs people take besides Fluconazole? *

What are other side effects people have besides Adrenal suppression? *

Cushing's Syndrome (obesity, a rounded face, increased fat): 7 people, 30.43%
Failure To Thrive (inadequate weight gain and physical growth in children): 3 people, 13.04%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 3 people, 13.04%
Cushingoid (obesity and weakening of the muscles): 3 people, 13.04%
Bone Density Decreased: 3 people, 13.04%
Pathological Fracture (broken bone caused by disease): 2 people, 8.70%
Candidiasis (candidiasis or thrush is a fungal infection): 2 people, 8.70%
Blood Sodium Decreased: 2 people, 8.70%
Adverse Event: 2 people, 8.70%
Bleeding Disorders: 1 person, 4.35%

What are the existing conditions these people have? *

Oral Candidiasis (fungal infection of mouth): 12 people, 52.17%
Septic Arthritis Streptococcal (serious infection of the joints caused by bacteria streptococcal): 7 people, 30.43%
Hiv Infection: 6 people, 26.09%
Asthma: 2 people, 8.70%
Respiratory Disorder (respiratory disease): 1 person, 4.35%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 1 person, 4.35%
Meningitis Coccidioides (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 1 person, 4.35%
Fungal Infection: 1 person, 4.35%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 4.35%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Fluconazole and have Adrenal suppression?

- Check whether Adrenal suppression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluconazole:

Fluconazole (70,481 reports)

Browse all side effects of Fluconazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adrenal suppression:

Adrenal suppression (118 drugs)

Browse all the conditions that are associated with Adrenal suppression:

Adrenal suppression (220 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluconazole (the active ingredients of Fluconazole) and Fluconazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.