Fluoxetine and Eyelid margin crusting - a phase IV clinical study of FDA data

Summary:

Eyelid margin crusting is reported as a side effect among people who take Fluoxetine (fluoxetine hydrochloride), especially for people who are female, 50-59 old, also take Dupixent, and have Asthma.

The phase IV clinical study analyzes which people have Eyelid margin crusting when taking Fluoxetine. It is created by eHealthMe based on reports of 94,370 people who have side effects when taking Fluoxetine from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Eyelid margin crusting?

Eyelid margin crusting (crusting at the lid margins, generally worse on waking) is found to be associated with 194 drugs and 279 conditions by eHealthMe. Check the latest studies of Eyelid margin crusting.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

94,370 people reported to have side effects when taking Fluoxetine.
Among them, 11 people (0.01%) have Eyelid margin crusting.

Could Fluoxetine cause Eyelid margin crusting?

Among these 11 people:

What is the gender of people who have Eyelid margin crusting when taking Fluoxetine? *

female: 100 %
male: 0.0 %

What is the age of people who have Eyelid margin crusting when taking Fluoxetine? *

What are other drugs people take besides Fluoxetine? *

What are other side effects people have besides Eyelid margin crusting? *

Rashes (redness): 3 people, 27.27%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 3 people, 27.27%
Eye Irritation: 3 people, 27.27%
Eye Pruritus (eye itching): 3 people, 27.27%
Weakness: 2 people, 18.18%
Fever: 2 people, 18.18%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 18.18%
Bipolar Disorder (mood disorder): 2 people, 18.18%
Constipation: 2 people, 18.18%
Diarrhea: 2 people, 18.18%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 18.18%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 18.18%
Bipolar Disorder (mood disorder): 2 people, 18.18%
Asthma: 2 people, 18.18%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 9.09%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 9.09%
Dry Eyes (lack of adequate tears): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine and have Eyelid margin crusting?

- Check whether Eyelid margin crusting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluoxetine:

Fluoxetine (98,824 reports)

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eyelid margin crusting:

Eyelid margin crusting (194 drugs)

Browse all the conditions that are associated with Eyelid margin crusting:

Eyelid margin crusting (279 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Fluoxetine) and Fluoxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.