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Folate and Acid reflux - a phase IV clinical study of FDA data

Summary:

Acid reflux is reported as a side effect among people who take Folate (folic acid), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Aredia, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Acid reflux when taking Folate. It is created by eHealthMe based on reports of 5,953 people who have side effects when taking Folate from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,539 Folate users. Check the latest studies of Folate.

What is Acid reflux?

Acid reflux (stomach acids rise up) is found to be associated with 3,293 drugs and 3,494 conditions by eHealthMe. Check the latest studies of Acid reflux.

On Nov, 19, 2025

5,953 people reported to have side effects when taking Folate.
Among them, 97 people (1.63%) have Acid reflux.

Could Folate cause Acid reflux?

Among these 97 people:

How long have people been on Folate when they have Acid reflux? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 50 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Acid reflux when taking Folate? *

  • female: 52.75 %
  • male: 47.25 %

What is the age of people who have Acid reflux when taking Folate? *

  • 0-1: 5.8 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 7.25 %
  • 40-49: 10.14 %
  • 50-59: 27.54 %
  • 60+: 49.28 %

What are other drugs people take besides Folate? *

  1. Aredia: 41 people, 42.27%
  2. Zometa: 40 people, 41.24%
  3. Nasonex: 36 people, 37.11%
  4. Lisinopril: 31 people, 31.96%
  5. Celebrex: 30 people, 30.93%
  6. Zofran: 28 people, 28.87%
  7. Flomax: 28 people, 28.87%
  8. Magnesium: 27 people, 27.84%
  9. Prednisone: 27 people, 27.84%
  10. Clonidine: 27 people, 27.84%

What are other side effects people have besides Acid reflux? *

  1. Anaemia (lack of blood): 50 people, 51.55%
  2. Pain: 45 people, 46.39%
  3. Pneumonia: 45 people, 46.39%
  4. Fatigue (feeling of tiredness): 45 people, 46.39%
  5. Diarrhea: 44 people, 45.36%
  6. Stress And Anxiety: 44 people, 45.36%
  7. Osteonecrosis Of Jaw (death of bone of jaw): 43 people, 44.33%
  8. Spinal Osteoarthritis (joint cartilage loss in spine): 42 people, 43.30%
  9. Constipation: 41 people, 42.27%
  10. Back Pain: 40 people, 41.24%

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 34 people, 35.05%
  2. Depression: 9 people, 9.28%
  3. Ovarian Cancer (cancer of ovary): 7 people, 7.22%
  4. Migraine (headache): 6 people, 6.19%
  5. High Blood Pressure: 6 people, 6.19%
  6. Pain: 5 people, 5.15%
  7. Anaemia (lack of blood): 5 people, 5.15%
  8. High Blood Cholesterol: 4 people, 4.12%
  9. Diabetes: 3 people, 3.09%
  10. Hiv Infection: 3 people, 3.09%

* Approximation only. Some reports may have incomplete information.

Do you take Folate and have Acid reflux?

- Check whether Acid reflux is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folate:

Acid reflux treatments and more:

How severe was Acid reflux and when was it recovered:

Expand to all the drugs that have ingredients of folic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Folate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acid reflux:

Browse all the conditions that are associated with Acid reflux:

Drugs similar to Folate and Acid reflux :

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folate) and Folate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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