Folic acid and Axonal neuropathy - a phase IV clinical study of FDA data

Summary:

Axonal neuropathy is reported as a side effect among people who take Folic acid (folic acid), especially for people who are female, 60+ old, also take Furosemide, and have High blood pressure.

The phase IV clinical study analyzes which people have Axonal neuropathy when taking Folic acid. It is created by eHealthMe based on reports of 162,497 people who have side effects when taking Folic acid from the FDA, and is updated regularly.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,028 Folic acid users. Check the latest studies of Folic acid.

What is Axonal neuropathy?

Axonal neuropathy (dysfunction of axon nerves) is found to be associated with 115 drugs and 383 conditions by eHealthMe. Check the latest studies of Axonal neuropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

162,497 people reported to have side effects when taking Folic acid.
Among them, 46 people (0.03%) have Axonal neuropathy.

Could Folic acid cause Axonal neuropathy?

Among these 46 people:

What is the gender of people who have Axonal neuropathy when taking Folic acid? *

female: 55 %
male: 45 %

What is the age of people who have Axonal neuropathy when taking Folic acid? *

What are other drugs people take besides Folic acid? *

What are other side effects people have besides Axonal neuropathy? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 20 people, 43.48%
Loss Of Proprioception (loss of senses of body and parts): 18 people, 39.13%
Stress And Anxiety: 8 people, 17.39%
Pain: 7 people, 15.22%
Gait Disturbance: 7 people, 15.22%
Muscle Atrophy (a decrease in the mass of the muscle): 6 people, 13.04%
Guillain-Barre Syndrome (the body's immune system attacks its peripheral nervous system): 6 people, 13.04%
Joint Contracture (a permanent shortening of a muscle or joint): 5 people, 10.87%
Overdose: 5 people, 10.87%
Nephrogenic Systemic Fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease): 5 people, 10.87%

What are the existing conditions these people have? *

High Blood Pressure: 38 people, 82.61%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 21 people, 45.65%
Vitamin B Complex Deficiency: 17 people, 36.96%
Insomnia (sleeplessness): 17 people, 36.96%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 15 people, 32.61%
Folate Deficiency (lack of folic acid): 14 people, 30.43%
Iron Deficiency Anaemia: 14 people, 30.43%
Diabetes: 5 people, 10.87%
Hypotension (abnormally low blood pressure): 5 people, 10.87%
High Blood Cholesterol: 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

Do you take Folic acid and have Axonal neuropathy?

- Check whether Axonal neuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folic acid:

Folic acid (165,028 reports)

Browse all side effects of Folic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Axonal neuropathy:

Axonal neuropathy (115 drugs)

Browse all the conditions that are associated with Axonal neuropathy:

Axonal neuropathy (383 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folic acid) and Folic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.