Folic acid and Eye oedema - a phase IV clinical study of FDA data

Summary:

Eye oedema is reported as a side effect among people who take Folic acid (folic acid), especially for people who are female, 60+ old, also take Warfarin Sodium, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Eye oedema when taking Folic acid. It is created by eHealthMe based on reports of 162,497 people who have side effects when taking Folic acid from the FDA, and is updated regularly.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,025 Folic acid users. Check the latest studies of Folic acid.

What is Eye oedema?

Eye oedema (swelling or thickening of the macula, the area of the retina responsible for central vision) is found to be associated with 304 drugs and 452 conditions by eHealthMe. Check the latest studies of Eye oedema.



On Jul, 10, 2026

162,497 people reported to have side effects when taking Folic acid.
Among them, 30 people (0.02%) have Eye oedema.

Could Folic acid cause Eye oedema?

Among these 30 people:

What is the gender of people who have Eye oedema when taking Folic acid? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Eye oedema when taking Folic acid? *

  • 0-1: 0.0 %
  • 2-9: 4.17 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 4.17 %
  • 50-59: 20.83 %
  • 60+: 70.83 %

What are other drugs people take besides Folic acid? *

  1. Simvastatin: 10 people, 33.33%
  2. Warfarin Sodium: 10 people, 33.33%
  3. Lorazepam: 9 people, 30.00%
  4. Spironolactone: 9 people, 30.00%
  5. Latanoprost: 9 people, 30.00%
  6. Metolazone: 9 people, 30.00%
  7. Tikosyn: 9 people, 30.00%
  8. Methotrexate: 8 people, 26.67%
  9. Bumetanide: 8 people, 26.67%
  10. Metoprolol Succinate: 6 people, 20.00%

What are other side effects people have besides Eye oedema? *

  1. Dyspnea (difficult or laboured breathing): 12 people, 40.00%
  2. Malaise (a feeling of general discomfort or uneasiness): 11 people, 36.67%
  3. Blood Creatinine Increased: 10 people, 33.33%
  4. Oedema (fluid collection in tissue): 10 people, 33.33%
  5. Visual Impairment: 10 people, 33.33%
  6. Diarrhea: 10 people, 33.33%
  7. Nasal Disorder (diseases of nose): 9 people, 30.00%
  8. Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 9 people, 30.00%
  9. Ventricular Extrasystoles (premature cardiac contraction): 9 people, 30.00%
  10. Blood Electrolytes Abnormal: 8 people, 26.67%

What are the existing conditions these people have? *

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 30.00%
  2. Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 2 people, 6.67%
  3. Pain: 2 people, 6.67%
  4. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 6.67%
  5. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.33%
  6. Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 1 person, 3.33%
  7. Angiodysplasia (small vascular malformation of the gut): 1 person, 3.33%
  8. Back Pain: 1 person, 3.33%
  9. Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 3.33%
  10. Conjunctivitis (pink eye): 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Folic acid and have Eye oedema?

- Check whether Eye oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folic acid:

Eye oedema treatments and more:

How severe was Eye oedema and when was it recovered:

Expand to all the drugs that have ingredients of folic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Folic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eye oedema:

Browse all the conditions that are associated with Eye oedema:


How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folic acid) and Folic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: