Folic acid and Metastasis - a phase IV clinical study of FDA data

Summary:

Metastasis is reported as a side effect among people who take Folic acid (folic acid), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Methotrexate, and have High blood pressure.

The phase IV clinical study analyzes which people have Metastasis when taking Folic acid. It is created by eHealthMe based on reports of 162,497 people who have side effects when taking Folic acid from the FDA, and is updated regularly.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,028 Folic acid users. Check the latest studies of Folic acid.

What is Metastasis?

Metastasis (spreadable cancer to other organ from origin) is found to be associated with 528 drugs and 842 conditions by eHealthMe. Check the latest studies of Metastasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

162,497 people reported to have side effects when taking Folic acid.
Among them, 52 people (0.03%) have Metastasis.

Among these 52 people:

How long have people been on Folic acid when they have Metastasis? *

What is the gender of people who have Metastasis when taking Folic acid? *

female: 54.17 %
male: 45.83 %

What is the age of people who have Metastasis when taking Folic acid? *

What are other drugs people take besides Folic acid? *

What are other side effects people have besides Metastasis? *

Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 7 people, 13.46%
Metastases To Liver (cancer spreads to liver): 6 people, 11.54%
Pleural Effusion (water on the lungs): 6 people, 11.54%
Haemolytic Anaemia (anaemia due to haemolysis): 4 people, 7.69%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 7.69%
Anaemia (lack of blood): 3 people, 5.77%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 3 people, 5.77%
Neoplasm Malignant (cancer tumour): 3 people, 5.77%
Pain: 3 people, 5.77%
Hemiparesis (weakness on one side of the body): 3 people, 5.77%

What are the existing conditions these people have? *

Urinary Tract Infection: 4 people, 7.69%
Osteoporosis (bones weak and more likely to break): 4 people, 7.69%
High Blood Pressure: 4 people, 7.69%
Joint Pain: 2 people, 3.85%
Breast Cancer: 2 people, 3.85%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 3.85%
Breast Cancer Metastatic: 1 person, 1.92%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 1.92%
Depression: 1 person, 1.92%
Folate Deficiency (lack of folic acid): 1 person, 1.92%

* Approximation only. Some reports may have incomplete information.

Do you take Folic acid and have Metastasis?

- Check whether Metastasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folic acid:

Folic acid (165,028 reports)

Metastasis treatments and more:

Metastasis (11,222 reports)

Browse all side effects of Folic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metastasis:

Metastasis (528 drugs)

Browse all the conditions that are associated with Metastasis:

Metastasis (842 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folic acid) and Folic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.