Folic acid and Neurotoxicity - a phase IV clinical study of FDA data

Summary:

Neurotoxicity is reported as a side effect among people who take Folic acid (folic acid), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Pantoprazole, and have Non-hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Neurotoxicity when taking Folic acid. It is created by eHealthMe based on reports of 162,497 people who have side effects when taking Folic acid from the FDA, and is updated regularly.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,027 Folic acid users. Check the latest studies of Folic acid.

What is Neurotoxicity?

Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system) is found to be associated with 677 drugs and 852 conditions by eHealthMe. Check the latest studies of Neurotoxicity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

162,497 people reported to have side effects when taking Folic acid.
Among them, 64 people (0.04%) have Neurotoxicity.

Among these 64 people:

How long have people been on Folic acid when they have Neurotoxicity? *

What is the gender of people who have Neurotoxicity when taking Folic acid? *

female: 50.85 %
male: 49.15 %

What is the age of people who have Neurotoxicity when taking Folic acid? *

What are other drugs people take besides Folic acid? *

What are other side effects people have besides Neurotoxicity? *

Encephalopathy (functioning of the brain is affected by some agent or condition): 8 people, 12.50%
Speech Impairment (Adult) (inability to speak (adult)): 8 people, 12.50%
Weakness: 7 people, 10.94%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 7 people, 10.94%
Hyperkalemia (damage to or disease of the kidney): 6 people, 9.38%
Confusional State: 6 people, 9.38%
Cerebellar Syndrome (impaired blood circulation to cerebellum due to lesion in artery): 6 people, 9.38%
Pneumonia: 6 people, 9.38%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 7.81%
Fever: 5 people, 7.81%

What are the existing conditions these people have? *

Radiation Associated Pain (pain due to radiation): 5 people, 7.81%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 7.81%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 7.81%
Herpes Zoster: 3 people, 4.69%
High Blood Pressure: 3 people, 4.69%
Device Related Infection: 3 people, 4.69%
Myositis (inflammation of the muscles): 3 people, 4.69%
Hypokalemia (low potassium): 2 people, 3.12%
Metastases To Central Nervous System (cancer spreads to central nervous system): 2 people, 3.12%
Herpes Zoster Infection Neurological (herpes zoster (hz) with neurological complications): 2 people, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Folic acid and have Neurotoxicity?

- Check whether Neurotoxicity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folic acid:

Folic acid (165,027 reports)

Neurotoxicity treatments and more:

Neurotoxicity (16,742 reports)

Browse all side effects of Folic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Neurotoxicity:

Neurotoxicity (677 drugs)

Browse all the conditions that are associated with Neurotoxicity:

Neurotoxicity (852 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folic acid) and Folic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.