Folic acid and Paroxysmal nocturnal haemoglobinuria - a phase IV clinical study of FDA data

Summary:

Paroxysmal nocturnal haemoglobinuria is reported as a side effect among people who take Folic acid (folic acid), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Soliris, and have Insomnia.

The phase IV clinical study analyzes which people have Paroxysmal nocturnal haemoglobinuria when taking Folic acid. It is created by eHealthMe based on reports of 162,497 people who have side effects when taking Folic acid from the FDA, and is updated regularly.

What is Folic acid?

Folic acid has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 165,025 Folic acid users. Check the latest studies of Folic acid.

What is Paroxysmal nocturnal haemoglobinuria?

Paroxysmal nocturnal haemoglobinuria (haemoglobin in the urine) is found to be associated with 37 drugs and 168 conditions by eHealthMe. Check the latest studies of Paroxysmal nocturnal haemoglobinuria.

On Jul, 05, 2026

162,497 people reported to have side effects when taking Folic acid.
Among them, 55 people (0.03%) have Paroxysmal nocturnal haemoglobinuria.

Could Folic acid cause Paroxysmal nocturnal haemoglobinuria?

Among these 55 people:

How long have people been on Folic acid when they have Paroxysmal nocturnal haemoglobinuria? *

What is the gender of people who have Paroxysmal nocturnal haemoglobinuria when taking Folic acid? *

female: 45.28 %
male: 54.72 %

What is the age of people who have Paroxysmal nocturnal haemoglobinuria when taking Folic acid? *

What are other drugs people take besides Folic acid? *

Soliris: 45 people, 81.82%
Furosemide: 12 people, 21.82%
Ambien: 11 people, 20.00%
Metoprolol Tartrate: 10 people, 18.18%
Coumadin: 9 people, 16.36%
Coreg: 9 people, 16.36%
Aspirin: 9 people, 16.36%
Norvasc: 8 people, 14.55%
Prednisone: 7 people, 12.73%
Benazepril Hydrochloride: 6 people, 10.91%

What are other side effects people have besides Paroxysmal nocturnal haemoglobinuria? *

Oedema Peripheral (superficial swelling): 14 people, 25.45%
Fatigue (feeling of tiredness): 13 people, 23.64%
Pain: 11 people, 20.00%
Rashes (redness): 11 people, 20.00%
Weight Decreased: 11 people, 20.00%
The Flu (the flu is caused by an influenza virus): 10 people, 18.18%
Anaemia (lack of blood): 10 people, 18.18%
Haemoglobinuria (the presence of free haemoglobin in the urine): 10 people, 18.18%
Joint Warmth: 9 people, 16.36%
Haemoglobin Decreased: 9 people, 16.36%

What are the existing conditions these people have? *

Insomnia (sleeplessness): 12 people, 21.82%
Pain: 5 people, 9.09%
High Blood Pressure: 4 people, 7.27%
Iron Overload: 4 people, 7.27%
Nervousness: 3 people, 5.45%
Aplastic Anemia: 3 people, 5.45%
Asthma: 3 people, 5.45%
Back Pain: 3 people, 5.45%
High Blood Cholesterol: 3 people, 5.45%
Nausea (feeling of having an urge to vomit): 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

Do you take Folic acid and have Paroxysmal nocturnal haemoglobinuria?

- Check whether Paroxysmal nocturnal haemoglobinuria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folic acid:

Folic acid (165,025 reports)

Browse all side effects of Folic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paroxysmal nocturnal haemoglobinuria:

Paroxysmal nocturnal haemoglobinuria (37 drugs)

Browse all the conditions that are associated with Paroxysmal nocturnal haemoglobinuria:

Paroxysmal nocturnal haemoglobinuria (168 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folic acid) and Folic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.