Glimepiride and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Glimepiride (glimepiride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Metformin, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Glimepiride. It is created by eHealthMe based on reports of 45,086 people who have side effects when taking Glimepiride from the FDA, and is updated regularly.

What is Glimepiride?

Glimepiride has active ingredients of glimepiride. It is often used in diabetes. eHealthMe is studying from 45,910 Glimepiride users. Check the latest studies of Glimepiride.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

45,086 people reported to have side effects when taking Glimepiride.
Among them, 47 people (0.1%) have Knee joint replacement.

Could Glimepiride cause Knee joint replacement?

Among these 47 people:

How long have people been on Glimepiride when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Glimepiride? *

female: 63.04 %
male: 36.96 %

What is the age of people who have Knee joint replacement when taking Glimepiride? *

What are other drugs people take besides Glimepiride? *

What are other side effects people have besides Knee joint replacement? *

Joint Pain: 10 people, 21.28%
Pain In Extremity: 8 people, 17.02%
Blood Glucose Decreased: 8 people, 17.02%
Dyspnea (difficult or laboured breathing): 6 people, 12.77%
Arthropathy: 6 people, 12.77%
Renal Disorder (kidney disease): 6 people, 12.77%
Head Injury: 6 people, 12.77%
Depression: 6 people, 12.77%
Gait Disturbance: 6 people, 12.77%
Nerve Injury: 5 people, 10.64%

What are the existing conditions these people have? *

High Blood Cholesterol: 9 people, 19.15%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 17.02%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 14.89%
High Blood Pressure: 6 people, 12.77%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 10.64%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 8.51%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.51%
Muscle Spasms (muscle contraction): 3 people, 6.38%
Stress And Anxiety: 3 people, 6.38%
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis): 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Glimepiride and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glimepiride:

Glimepiride (45,910 reports)

Browse all side effects of Glimepiride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on glimepiride (the active ingredients of Glimepiride) and Glimepiride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.