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Glucophage xr and Thrombocytopenia - a phase IV clinical study of FDA data

Summary:

Thrombocytopenia is reported as a side effect among people who take Glucophage xr (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Allopurinol, and have Small cell lung cancer extensive stage.

The phase IV clinical study analyzes which people have Thrombocytopenia when taking Glucophage xr. It is created by eHealthMe based on reports of 3,773 people who have side effects when taking Glucophage xr from the FDA, and is updated regularly.

What is Glucophage xr?

Glucophage xr has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 3,939 Glucophage xr users. Check the latest studies of Glucophage xr.

What is Thrombocytopenia?

Thrombocytopenia (decrease of platelets in blood) is found to be associated with 2,789 drugs and 4,873 conditions by eHealthMe. Check the latest studies of Thrombocytopenia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

3,773 people reported to have side effects when taking Glucophage xr.
Among them, 28 people (0.74%) have Thrombocytopenia.

Could Glucophage xr cause Thrombocytopenia?

Among these 28 people:

How long have people been on Glucophage xr when they have Thrombocytopenia? *

  • < 1 month: 66.67 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Thrombocytopenia when taking Glucophage xr? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Thrombocytopenia when taking Glucophage xr? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 4.55 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 31.82 %
  • 60+: 63.64 %

What are other drugs people take besides Glucophage xr? *

  1. Allopurinol: 12 people, 42.86%
  2. Humalog: 10 people, 35.71%
  3. Synthroid: 10 people, 35.71%
  4. Nystatin: 8 people, 28.57%
  5. Ondansetron: 8 people, 28.57%
  6. Etoposide: 7 people, 25.00%
  7. Acetaminophen: 7 people, 25.00%
  8. Metronidazole: 7 people, 25.00%
  9. Xylometazoline Hydrochloride: 7 people, 25.00%
  10. Dexamethasone: 7 people, 25.00%

What are other side effects people have besides Thrombocytopenia? *

  1. Anaemia (lack of blood): 14 people, 50.00%
  2. Fatigue (feeling of tiredness): 11 people, 39.29%
  3. Nausea (feeling of having an urge to vomit): 10 people, 35.71%
  4. Diarrhea: 8 people, 28.57%
  5. Mucosal Inflammation (infection of mucous membrane): 7 people, 25.00%
  6. Hair Loss: 7 people, 25.00%
  7. Dyspnea Exertional: 7 people, 25.00%
  8. Sinusitis (inflammation of sinus): 7 people, 25.00%
  9. Red Blood Cell Count Decreased: 3 people, 10.71%
  10. Leukocytosis (increased white blood cells): 3 people, 10.71%

What are the existing conditions these people have? *

  1. Small Cell Lung Cancer Extensive Stage (small cell lung cancer that has spread (metastasized) to other regions of the body such as another lobe of the lung or the brain): 5 people, 17.86%
  2. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 3 people, 10.71%
  3. Primary Myelofibrosis (primary disorder of the bone marrow): 3 people, 10.71%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 10.71%
  5. Constipation: 3 people, 10.71%
  6. Insomnia (sleeplessness): 3 people, 10.71%
  7. Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 3 people, 10.71%
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 10.71%
  9. Seasonal Allergy (allergic condition due to certain season): 3 people, 10.71%
  10. Anaemia (lack of blood): 3 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage xr and have Thrombocytopenia?

- Check whether Thrombocytopenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage xr:

Thrombocytopenia treatments and more:

How severe was Thrombocytopenia and when was it recovered:

Expand to all the drugs that have ingredients of metformin hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Glucophage xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thrombocytopenia:

Browse all the conditions that are associated with Thrombocytopenia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage xr) and Glucophage xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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