Glucophage and Calculus bladder - a phase IV clinical study of FDA data

Summary:

Calculus bladder is reported as a side effect among people who take Glucophage (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Lantus, and have Cough.

The phase IV clinical study analyzes which people have Calculus bladder when taking Glucophage. It is created by eHealthMe based on reports of 59,839 people who have side effects when taking Glucophage from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Calculus bladder?

Calculus bladder (bladder stone) is found to be associated with 209 drugs and 621 conditions by eHealthMe. Check the latest studies of Calculus bladder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

59,839 people reported to have side effects when taking Glucophage.
Among them, 12 people (0.02%) have Calculus bladder.

Could Glucophage cause Calculus bladder?

Among these 12 people:

How long have people been on Glucophage when they have Calculus bladder? *

What is the gender of people who have Calculus bladder when taking Glucophage? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Calculus bladder when taking Glucophage? *

What are other drugs people take besides Glucophage? *

What are other side effects people have besides Calculus bladder? *

Weakness: 5 people, 41.67%
Diabetes Mellitus Inadequate Control: 5 people, 41.67%
Hepatic Steatosis (fatty liver disease): 4 people, 33.33%
Blood Glucose Increased: 3 people, 25.00%
Acute Kidney Failure: 3 people, 25.00%
Hypoglycemia (low blood sugar): 3 people, 25.00%
Urinary Tract Infection: 3 people, 25.00%
Pleural Effusion (water on the lungs): 3 people, 25.00%
Haematuria (presence of blood in urine): 3 people, 25.00%
Glycosylated Haemoglobin Increased: 3 people, 25.00%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 16.67%
High Blood Pressure: 2 people, 16.67%
Cough: 2 people, 16.67%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Calculus bladder?

- Check whether Calculus bladder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage:

Glucophage (60,851 reports)

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Calculus bladder:

Calculus bladder (209 drugs)

Browse all the conditions that are associated with Calculus bladder:

Calculus bladder (621 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.