Glucophage and Poor peripheral circulation - a phase IV clinical study of FDA data

Summary:

Poor peripheral circulation is reported as a side effect among people who take Glucophage (metformin hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Rezulin, and have Neuropathy peripheral.

The phase IV clinical study analyzes which people have Poor peripheral circulation when taking Glucophage. It is created by eHealthMe based on reports of 59,839 people who have side effects when taking Glucophage from the FDA, and is updated regularly.

What is Glucophage?

Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.

What is Poor peripheral circulation?

Poor peripheral circulation is found to be associated with 532 drugs and 695 conditions by eHealthMe. Check the latest studies of Poor peripheral circulation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

59,839 people reported to have side effects when taking Glucophage.
Among them, 28 people (0.05%) have Poor peripheral circulation.

Could Glucophage cause Poor peripheral circulation?

Among these 28 people:

How long have people been on Glucophage when they have Poor peripheral circulation? *

What is the gender of people who have Poor peripheral circulation when taking Glucophage? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Poor peripheral circulation when taking Glucophage? *

What are other drugs people take besides Glucophage? *

What are other side effects people have besides Poor peripheral circulation? *

Weight Increased: 8 people, 28.57%
Back Pain: 7 people, 25.00%
Fatigue (feeling of tiredness): 7 people, 25.00%
Abdominal Pain Upper: 6 people, 21.43%
Ascites (accumulation of fluid in the abdominal cavity): 6 people, 21.43%
Oedema Lower Limb (fluid collection in tissue of lower leg): 5 people, 17.86%
Splenomegaly (enlargement of spleen): 5 people, 17.86%
Confusion: 5 people, 17.86%
Pain In Limb: 4 people, 14.29%
Heart Attack: 4 people, 14.29%

What are the existing conditions these people have? *

Wound: 6 people, 21.43%
Pain: 6 people, 21.43%
Neuropathy Peripheral (surface nerve damage): 6 people, 21.43%
Pain In Extremity: 3 people, 10.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.14%
Promotion Of Peripheral Circulation: 1 person, 3.57%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 3.57%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 1 person, 3.57%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 3.57%
High Blood Pressure: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Glucophage and have Poor peripheral circulation?

- Check whether Poor peripheral circulation is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Glucophage:

Glucophage (60,851 reports)

Browse all side effects of Glucophage:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Poor peripheral circulation:

Poor peripheral circulation (532 drugs)

Browse all the conditions that are associated with Poor peripheral circulation:

Poor peripheral circulation (695 conditions)

Related publications that referenced our studies

T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride (the active ingredients of Glucophage) and Glucophage (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.