Haldol and Pyramidal tract syndrome - a phase IV clinical study of FDA data

Summary:

Pyramidal tract syndrome is reported as a side effect among people who take Haldol (haloperidol), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Abilify, and have Dementia alzheimer's type.

The phase IV clinical study analyzes which people have Pyramidal tract syndrome when taking Haldol. It is created by eHealthMe based on reports of 22,656 people who have side effects when taking Haldol from the FDA, and is updated regularly.

What is Haldol?

Haldol has active ingredients of haloperidol. It is often used in schizophrenia. eHealthMe is studying from 23,102 Haldol users. Check the latest studies of Haldol.

What is Pyramidal tract syndrome?

Pyramidal tract syndrome (disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord) is found to be associated with 41 drugs and 164 conditions by eHealthMe. Check the latest studies of Pyramidal tract syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

22,656 people reported to have side effects when taking Haldol.
Among them, 16 people (0.07%) have Pyramidal tract syndrome.

Could Haldol cause Pyramidal tract syndrome?

Among these 16 people:

How long have people been on Haldol when they have Pyramidal tract syndrome? *

What is the gender of people who have Pyramidal tract syndrome when taking Haldol? *

female: 13.33 %
male: 86.67 %

What is the age of people who have Pyramidal tract syndrome when taking Haldol? *

What are other drugs people take besides Haldol? *

Duphalac: 12 people, 75.00%
Abilify: 12 people, 75.00%
Valium: 2 people, 12.50%
Paracetamol: 1 person, 6.25%
Lisinopril: 1 person, 6.25%

What are other side effects people have besides Pyramidal tract syndrome? *

Acute Kidney Failure: 12 people, 75.00%
Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 12 people, 75.00%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 12 people, 75.00%
Respiratory Distress (difficulty in breathing): 12 people, 75.00%
Mydriasis (a dilation of the pupil): 12 people, 75.00%
Loss Of Consciousness: 12 people, 75.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 11 people, 68.75%
Confusional State: 2 people, 12.50%
Urinary Tract Neoplasm (urinary tract tumour): 1 person, 6.25%
Hypotonia (low muscle tone): 1 person, 6.25%

What are the existing conditions these people have? *

Stress And Anxiety: 1 person, 6.25%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
Depression: 1 person, 6.25%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Haldol and have Pyramidal tract syndrome?

- Check whether Pyramidal tract syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Haldol:

Haldol (23,102 reports)

Browse all side effects of Haldol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pyramidal tract syndrome:

Pyramidal tract syndrome (41 drugs)

Browse all the conditions that are associated with Pyramidal tract syndrome:

Pyramidal tract syndrome (164 conditions)

Related publications that referenced our studies

Obayi, O., & Tagbo, N. , "Bilateral Pedal Oedema Associated with Intramuscular Haloperidol–A Rare Observation", International Neuropsychiatric Disease Journal, 2018 Jan .
Obayi, O., & Tagbo, N. , "Bilateral Pedal Oedema Associated with Intramuscular Haloperidol–A Rare Observation", International Neuropsychiatric Disease Journal, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on haloperidol (the active ingredients of Haldol) and Haldol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.