Hctz and Joint effusion - a phase IV clinical study of FDA data

Summary:

Joint effusion is reported as a side effect among people who take Hctz (hydrochlorothiazide), especially for people who are female, 60+ old, also take Cymbalta, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Joint effusion when taking Hctz. It is created by eHealthMe based on reports of 23,493 people who have side effects when taking Hctz from the FDA, and is updated regularly.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

What is Joint effusion?

Joint effusion (presence of extra fluid in joint covering) is found to be associated with 868 drugs and 750 conditions by eHealthMe. Check the latest studies of Joint effusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

23,493 people reported to have side effects when taking Hctz.
Among them, 18 people (0.08%) have Joint effusion.

Among these 18 people:

What is the gender of people who have Joint effusion when taking Hctz? *

female: 94.44 %
male: 5.56 %

What is the age of people who have Joint effusion when taking Hctz? *

What are other drugs people take besides Hctz? *

What are other side effects people have besides Joint effusion? *

Joint Pain: 10 people, 55.56%
Headache (pain in head): 8 people, 44.44%
Pain In Extremity: 8 people, 44.44%
Weakness: 6 people, 33.33%
Joint Swelling: 6 people, 33.33%
Back Pain: 6 people, 33.33%
Bladder Dysfunction: 5 people, 27.78%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 5 people, 27.78%
Blood Potassium Decreased: 5 people, 27.78%
Gastric Disorder (disease of stomach): 5 people, 27.78%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 66.67%
Pain: 5 people, 27.78%
Stress And Anxiety: 3 people, 16.67%
Depression: 3 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 16.67%
Migraine (headache): 3 people, 16.67%
Gastric Disorder (disease of stomach): 3 people, 16.67%
High Blood Cholesterol: 3 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Hctz and have Joint effusion?

- Check whether Joint effusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hctz:

Hctz (24,823 reports)

Joint effusion treatments and more:

Joint effusion (9,947 reports)

Browse all side effects of Hctz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint effusion:

Joint effusion (868 drugs)

Browse all the conditions that are associated with Joint effusion:

Joint effusion (750 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hctz) and Hctz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.