Hctz and Muscle rupture - a phase IV clinical study of FDA data

Summary:

Muscle rupture is reported as a side effect among people who take Hctz (hydrochlorothiazide), especially for people who are male, 60+ old, also take Metformin, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Muscle rupture when taking Hctz. It is created by eHealthMe based on reports of 23,493 people who have side effects when taking Hctz from the FDA, and is updated regularly.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

What is Muscle rupture?

Muscle rupture (tear in muscle) is found to be associated with 395 drugs and 509 conditions by eHealthMe. Check the latest studies of Muscle rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

23,493 people reported to have side effects when taking Hctz.
Among them, 19 people (0.08%) have Muscle rupture.

Among these 19 people:

What is the gender of people who have Muscle rupture when taking Hctz? *

female: 50 %
male: 50 %

What is the age of people who have Muscle rupture when taking Hctz? *

What are other drugs people take besides Hctz? *

What are other side effects people have besides Muscle rupture? *

Weakness: 10 people, 52.63%
Dizziness: 9 people, 47.37%
Fatigue (feeling of tiredness): 9 people, 47.37%
Muscle Aches (muscle pain): 9 people, 47.37%
Malaise (a feeling of general discomfort or uneasiness): 9 people, 47.37%
Dyspnea (difficult or laboured breathing): 8 people, 42.11%
Swallowing Difficulty: 8 people, 42.11%
Stress And Anxiety: 8 people, 42.11%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 7 people, 36.84%
Haematocrit Abnormal: 7 people, 36.84%

What are the existing conditions these people have? *

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 7 people, 36.84%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 7 people, 36.84%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 36.84%
Muscle Disorder (muscle disease): 4 people, 21.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
Blood Potassium Decreased: 2 people, 10.53%
Sleep Disorder: 2 people, 10.53%
Joint Swelling: 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Nerve Compression: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Hctz and have Muscle rupture?

- Check whether Muscle rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hctz:

Hctz (24,823 reports)

Muscle rupture treatments and more:

Muscle rupture (4,655 reports)

Browse all side effects of Hctz:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rupture:

Muscle rupture (395 drugs)

Browse all the conditions that are associated with Muscle rupture:

Muscle rupture (509 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hctz) and Hctz (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.