Heparin and Hypofibrinogenaemia - a phase IV clinical study of FDA data

Summary:

Hypofibrinogenaemia is reported as a side effect among people who take Heparin (heparin sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Argatroban, and have Acute lymphocytic leukemia (all).

The phase IV clinical study analyzes which people have Hypofibrinogenaemia when taking Heparin. It is created by eHealthMe based on reports of 91,860 people who have side effects when taking Heparin from the FDA, and is updated regularly.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

What is Hypofibrinogenaemia?

Hypofibrinogenaemia (a decrease in plasma fibrogen level) is found to be associated with 74 drugs and 107 conditions by eHealthMe. Check the latest studies of Hypofibrinogenaemia.

On Jul, 28, 2026

91,860 people reported to have side effects when taking Heparin.
Among them, 34 people (0.04%) have Hypofibrinogenaemia.

Could Heparin cause Hypofibrinogenaemia?

Among these 34 people:

How long have people been on Heparin when they have Hypofibrinogenaemia? *

What is the gender of people who have Hypofibrinogenaemia when taking Heparin? *

female: 57.69 %
male: 42.31 %

What is the age of people who have Hypofibrinogenaemia when taking Heparin? *

What are other drugs people take besides Heparin? *

Argatroban: 5 people, 14.71%
Ondansetron: 4 people, 11.76%
Apixaban: 4 people, 11.76%
Vincristine Sulfate: 3 people, 8.82%
Morphine: 3 people, 8.82%
Piperacillin And Tazobactam: 3 people, 8.82%
Furosemide: 3 people, 8.82%
Epinephrine: 3 people, 8.82%
Dexamethasone: 3 people, 8.82%
Amlodipine: 3 people, 8.82%

What are other side effects people have besides Hypofibrinogenaemia? *

Drug Ineffective: 7 people, 20.59%
Heparin-Induced Thrombocytopenia: 5 people, 14.71%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 14.71%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 3 people, 8.82%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 8.82%
Haemorrhage Intracranial (bleeding within the skull): 3 people, 8.82%
Thrombocytopenia (decrease of platelets in blood): 2 people, 5.88%
Hyperbilirubinaemia (excess of bilirubin in the blood): 2 people, 5.88%
Constipation: 1 person, 2.94%
Cytomegalovirus Infection: 1 person, 2.94%

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 10 people, 29.41%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 6 people, 17.65%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 14.71%
Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 11.76%
Pulseless Electrical Activity: 3 people, 8.82%
Acinetobacter Infection (infection by group of bacteria commonly found in soil and water): 2 people, 5.88%
Vena Cava Thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart): 1 person, 2.94%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 2.94%
Renal Vein Thrombosis (blood clot in renal vein): 1 person, 2.94%
Osteomyelitis (infection of bone): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Heparin and have Hypofibrinogenaemia?

- Check whether Hypofibrinogenaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Heparin:

Heparin (92,141 reports)

Browse all side effects of Heparin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypofibrinogenaemia:

Hypofibrinogenaemia (74 drugs)

Browse all the conditions that are associated with Hypofibrinogenaemia:

Hypofibrinogenaemia (107 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on heparin sodium (the active ingredients of Heparin) and Heparin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.