Heparin and Type iv hypersensitivity reaction - a phase IV clinical study of FDA data

Summary:

Type iv hypersensitivity reaction is reported as a side effect among people who take Heparin (heparin sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Polyethylene Glycol 3350, and have Pelvic abscess.

The phase IV clinical study analyzes which people have Type iv hypersensitivity reaction when taking Heparin. It is created by eHealthMe based on reports of 91,860 people who have side effects when taking Heparin from the FDA, and is updated regularly.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

What is Type iv hypersensitivity reaction?

Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop) is found to be associated with 193 drugs and 415 conditions by eHealthMe. Check the latest studies of Type iv hypersensitivity reaction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

91,860 people reported to have side effects when taking Heparin.
Among them, 28 people (0.03%) have Type iv hypersensitivity reaction.

Could Heparin cause Type iv hypersensitivity reaction?

Among these 28 people:

How long have people been on Heparin when they have Type iv hypersensitivity reaction? *

What is the gender of people who have Type iv hypersensitivity reaction when taking Heparin? *

female: 80 %
male: 20 %

What is the age of people who have Type iv hypersensitivity reaction when taking Heparin? *

What are other drugs people take besides Heparin? *

Dilaudid: 6 people, 21.43%
Crestor: 6 people, 21.43%
Imipenem And Cilastatin: 6 people, 21.43%
Benadryl: 6 people, 21.43%
Celecoxib: 6 people, 21.43%
Clonazepam: 6 people, 21.43%
Tylenol: 6 people, 21.43%
Synthroid: 6 people, 21.43%
Polyethylene Glycol 3350: 6 people, 21.43%
Furosemide: 4 people, 14.29%

What are other side effects people have besides Type iv hypersensitivity reaction? *

Hepatic Enzyme Increased: 6 people, 21.43%
Rash Morbilliform (a rash that looks like measles): 6 people, 21.43%
Pain: 2 people, 7.14%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 7.14%
Drug Ineffective: 2 people, 7.14%
Drug Hypersensitivity: 2 people, 7.14%
Itching: 2 people, 7.14%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 7.14%
Myocarditis (inflammation of heart muscle myocardium): 2 people, 7.14%
Oedema Peripheral (superficial swelling): 2 people, 7.14%

What are the existing conditions these people have? *

Procedural Pain: 6 people, 21.43%
Pelvic Abscess: 6 people, 21.43%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 10.71%
Pneumonia: 2 people, 7.14%
Wound Infection Staphylococcal: 1 person, 3.57%
Stress Gastritis (swelling (inflammation) and weakening of the stomach lining that occurs during a serious illness): 1 person, 3.57%
Pathogen Resistance: 1 person, 3.57%
Osteitis (a general term for inflammation of bone): 1 person, 3.57%
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 1 person, 3.57%
Iron Deficiency Anaemia: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Heparin and have Type iv hypersensitivity reaction?

- Check whether Type iv hypersensitivity reaction is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Heparin:

Heparin (92,141 reports)

Browse all side effects of Heparin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (193 drugs)

Browse all the conditions that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (415 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on heparin sodium (the active ingredients of Heparin) and Heparin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.