Hiprex and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Hiprex (methenamine hippurate), especially for people who are female, 60+ old, also take Vitamin D3, and have Nausea.

The phase IV clinical study analyzes which people have Hyponatremia when taking Hiprex. It is created by eHealthMe based on reports of 812 people who have side effects when taking Hiprex from the FDA, and is updated regularly.

What is Hiprex?

Hiprex has active ingredients of methenamine hippurate. It is often used in urinary tract infection. eHealthMe is studying from 900 Hiprex users. Check the latest studies of Hiprex.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,938 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Apr, 15, 2026

812 people reported to have side effects when taking Hiprex.
Among them, 12 people (1.48%) have Hyponatremia.

Among these 12 people:

What is the gender of people who have Hyponatremia when taking Hiprex? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Hyponatremia when taking Hiprex? *

What are other drugs people take besides Hiprex? *

What are other side effects people have besides Hyponatremia? *

Weakness: 4 people, 33.33%
Back Pain: 4 people, 33.33%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 3 people, 25.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 25.00%
Bladder Outlet Obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded): 3 people, 25.00%
Carpal Tunnel Syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 3 people, 25.00%
Colitis (inflammation of colon): 3 people, 25.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 25.00%
Dyslipidaemia (abnormal amount of lipids): 3 people, 25.00%
Enlarged Prostate: 3 people, 25.00%

What are the existing conditions these people have? *

Nausea And Vomiting: 5 people, 41.67%
Nausea (feeling of having an urge to vomit): 5 people, 41.67%
Bladder Disorder: 4 people, 33.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 25.00%
High Blood Pressure: 3 people, 25.00%
Affective Disorder (mental disorder): 3 people, 25.00%
Seasonal Allergy (allergic condition due to certain season): 3 people, 25.00%
Restless Leg Syndrome (a powerful urge to move your legs): 3 people, 25.00%
Asthma: 3 people, 25.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hiprex and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hiprex:

Hiprex (900 reports)

Hyponatremia treatments and more:

Hyponatremia (72,436 reports)

Browse all side effects of Hiprex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Hyponatremia (1,938 drugs)

Browse all the conditions that are associated with Hyponatremia:

Hyponatremia (2,272 conditions)

Related publications that referenced our studies

Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .
Choi N, Lee JY, Sunwoo JS, Kwon KI, Roh H, Ahn MY, Lee KB, "Hyponatremia during Acyclovir Treatment of Bell’s Palsy", Journal of the Korean Neurological Association, 2017 Aug .
Koza Y, Ta? MH, ?im?ek Z, Gündo?du F, "Hyponatremia and heart failure: the overlooked piece of the puzzle", Anatolian journal of cardiology, 2016 Jan .
Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S, "A case of losartan-induced severe hyponatremia", Journal of pharmacology & pharmacotherapeutics, 2015 Jan .
Gupta E, Kunjal R, Cury JD, "Severe hyponatremia due to valproic acid toxicity", Journal of clinical medicine research, 2015 Jan .
Kate N, Grover S, Kumar S, Modi M, "Bupropion-induced hyponatremia", General hospital psychiatry, 2013 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methenamine hippurate (the active ingredients of Hiprex) and Hiprex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.