Hycamtin and Intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Intestinal obstruction is reported as a side effect among people who take Hycamtin (topotecan hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Paclitaxel, and have Ovarian cancer recurrent.

The phase IV clinical study analyzes which people have Intestinal obstruction when taking Hycamtin. It is created by eHealthMe based on reports of 2,349 people who have side effects when taking Hycamtin from the FDA, and is updated regularly.

What is Hycamtin?

Hycamtin has active ingredients of topotecan hydrochloride. eHealthMe is studying from 2,351 Hycamtin users. Check the latest studies of Hycamtin.

What is Intestinal obstruction?

Intestinal obstruction is found to be associated with 1,885 drugs and 2,619 conditions by eHealthMe. Check the latest studies of Intestinal obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,349 people reported to have side effects when taking Hycamtin.
Among them, 31 people (1.32%) have Intestinal obstruction.

Could Hycamtin cause Intestinal obstruction?

Among these 31 people:

How long have people been on Hycamtin when they have Intestinal obstruction? *

What is the gender of people who have Intestinal obstruction when taking Hycamtin? *

female: 96.55 %
male: 3.45 %

What is the age of people who have Intestinal obstruction when taking Hycamtin? *

What are other drugs people take besides Hycamtin? *

Paclitaxel: 4 people, 12.90%
Neupogen: 3 people, 9.68%
Avastin: 3 people, 9.68%
Vytorin: 2 people, 6.45%
Synthroid: 2 people, 6.45%
Compazine: 2 people, 6.45%
Dexamethasone: 2 people, 6.45%
Neulasta: 2 people, 6.45%
Atenolol: 2 people, 6.45%
Granisetron Hydrochloride: 1 person, 3.23%

What are other side effects people have besides Intestinal obstruction? *

Thrombocytopenia (decrease of platelets in blood): 14 people, 45.16%
Nausea (feeling of having an urge to vomit): 9 people, 29.03%
White Blood Cell Count Decreased: 8 people, 25.81%
Red Blood Cell Count Decreased: 7 people, 22.58%
Anaemia (lack of blood): 7 people, 22.58%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 16.13%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 12.90%
Fever: 4 people, 12.90%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 4 people, 12.90%
Constipation: 4 people, 12.90%

What are the existing conditions these people have? *

Ovarian Cancer Recurrent (reoccurrence of ovary cancer): 9 people, 29.03%
Ovarian Cancer (cancer of ovary): 3 people, 9.68%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 3.23%
Ovarian Cancer Metastatic (cancer of ovary spreads to other organ or parts): 1 person, 3.23%
Nausea And Vomiting: 1 person, 3.23%
Brain Neoplasm (tumour of brain): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Hycamtin and have Intestinal obstruction?

- Check whether Intestinal obstruction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hycamtin:

Hycamtin (2,351 reports)

Browse all side effects of Hycamtin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal obstruction:

Intestinal obstruction (1,885 drugs)

Browse all the conditions that are associated with Intestinal obstruction:

Intestinal obstruction (2,619 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on topotecan hydrochloride (the active ingredients of Hycamtin) and Hycamtin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.