Hycodan and Fever - a phase IV clinical study of FDA data

Summary:

Fever is reported as a side effect among people who take Hycodan (homatropine methylbromide; hydrocodone bitartrate), especially for people who are male, 60+ old, also take Prilosec, and have Pain.

The phase IV clinical study analyzes which people have Fever when taking Hycodan. It is created by eHealthMe based on reports of 713 people who have side effects when taking Hycodan from the FDA, and is updated regularly.

What is Hycodan?

Hycodan has active ingredients of homatropine methylbromide; hydrocodone bitartrate. It is often used in cough. eHealthMe is studying from 769 Hycodan users. Check the latest studies of Hycodan.

What is Fever?

Fever is found to be associated with 3,491 drugs and 6,182 conditions by eHealthMe. Check the latest studies of Fever.

On Mar, 22, 2026

713 people reported to have side effects when taking Hycodan.
Among them, 48 people (6.73%) have Fever.

Among these 48 people:

What is the gender of people who have Fever when taking Hycodan? *

female: 44.68 %
male: 55.32 %

What is the age of people who have Fever when taking Hycodan? *

What are other drugs people take besides Hycodan? *

What are other side effects people have besides Fever? *

Nausea (feeling of having an urge to vomit): 15 people, 31.25%
Pleural Effusion (water on the lungs): 10 people, 20.83%
Weakness: 8 people, 16.67%
Chest Pain: 8 people, 16.67%
Chills (felling of cold): 8 people, 16.67%
Haemoglobin Decreased: 7 people, 14.58%
Dehydration (dryness resulting from the removal of water): 7 people, 14.58%
Fatigue (feeling of tiredness): 7 people, 14.58%
Dyspnea (difficult or laboured breathing): 6 people, 12.50%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 12.50%

What are the existing conditions these people have? *

Pain: 8 people, 16.67%
Nausea (feeling of having an urge to vomit): 5 people, 10.42%
Breast Cancer Metastatic: 4 people, 8.33%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 8.33%
Dyspnea (difficult or laboured breathing): 3 people, 6.25%
Pneumonia: 3 people, 6.25%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 4.17%
Multiple Myeloma (cancer of the plasma cells): 2 people, 4.17%
Asthma: 2 people, 4.17%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Hycodan and have Fever?

- Check whether Fever is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hycodan:

Hycodan (769 reports)

Fever treatments and more:

Fever (498,666 reports)

How severe was Fever and when was it recovered:

Fever in Hycodan

Expand to all the drugs that have ingredients of homatropine methylbromide; hydrocodone bitartrate:

Fever and drugs with ingredients of homatropine methylbromide; hydrocodone bitartrate (846 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hycodan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fever:

Fever (3,491 drugs)

Browse all the conditions that are associated with Fever:

Fever (6,182 conditions)

Related publications that referenced our studies

Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .
Schiller D, Maieron A, Sch?fl R, Donnerer J, "Drug fever due to a single dose of pantoprazole", Pharmacology, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on homatropine methylbromide; hydrocodone bitartrate (the active ingredients of Hycodan) and Hycodan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.