Hydramine and Areflexia - a phase IV clinical study of FDA data

Summary:

Areflexia is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 10-19 old, have been taking the drug for 1 - 6 months also take Fluoxetine, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Areflexia when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Areflexia?

Areflexia (absence of a reflex) is found to be associated with 437 drugs and 718 conditions by eHealthMe. Check the latest studies of Areflexia.

On Jul, 14, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 46 people (0.04%) have Areflexia.

Among these 46 people:

How long have people been on Hydramine when they have Areflexia? *

What is the gender of people who have Areflexia when taking Hydramine? *

female: 80.49 %
male: 19.51 %

What is the age of people who have Areflexia when taking Hydramine? *

What are other drugs people take besides Hydramine? *

What are other side effects people have besides Areflexia? *

Stress And Anxiety: 24 people, 52.17%
Mydriasis (a dilation of the pupil): 23 people, 50.00%
Amaurosis (partial or total blindness without visible change in the eye): 22 people, 47.83%
Facial Paralysis (loss of function of face muscle): 22 people, 47.83%
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 21 people, 45.65%
Toxic Encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances): 20 people, 43.48%
Hallucinations (sensations that appear real but are created by your mind): 16 people, 34.78%
Confusional State: 13 people, 28.26%
Unresponsive To Stimuli: 11 people, 23.91%
Hoarseness Or Changing Voice: 11 people, 23.91%

What are the existing conditions these people have? *

Stress And Anxiety: 21 people, 45.65%
Malaria (a parasitic disease due to mosquito bite): 20 people, 43.48%
Pneumonia Mycoplasmal (mycoplasma pneumonia (mp) is a contagious respiratory infection): 17 people, 36.96%
Suicide Attempt: 6 people, 13.04%
Abnormal Behavior: 6 people, 13.04%
Sleep Disorder: 4 people, 8.70%
Toxic Encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances): 2 people, 4.35%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 2 people, 4.35%
Metastases To Bone (cancer spreads to bone): 2 people, 4.35%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Areflexia?

- Check whether Areflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Areflexia treatments and more:

Areflexia (3,364 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Areflexia:

Areflexia (437 drugs)

Browse all the conditions that are associated with Areflexia:

Areflexia (718 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.