Hydramine and Posterior reversible encephalopathy syndrome - a phase IV clinical study of FDA data

Summary:

Posterior reversible encephalopathy syndrome is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Vancomycin, and have Pain.

The phase IV clinical study analyzes which people have Posterior reversible encephalopathy syndrome when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Posterior reversible encephalopathy syndrome?

Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss) is found to be associated with 467 drugs and 1,010 conditions by eHealthMe. Check the latest studies of Posterior reversible encephalopathy syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 25 people (0.02%) have Posterior reversible encephalopathy syndrome.

Could Hydramine cause Posterior reversible encephalopathy syndrome?

Among these 25 people:

How long have people been on Hydramine when they have Posterior reversible encephalopathy syndrome? *

What is the gender of people who have Posterior reversible encephalopathy syndrome when taking Hydramine? *

female: 80 %
male: 20 %

What is the age of people who have Posterior reversible encephalopathy syndrome when taking Hydramine? *

What are other drugs people take besides Hydramine? *

Vancomycin: 8 people, 32.00%
Acetaminophen: 6 people, 24.00%
Pantoprazole: 6 people, 24.00%
Furosemide: 6 people, 24.00%
Piperacillin And Tazobactam: 6 people, 24.00%
Calcium: 5 people, 20.00%
Ondansetron: 5 people, 20.00%
Morphine: 5 people, 20.00%
Gabapentin: 5 people, 20.00%
Methylprednisolone: 5 people, 20.00%

What are other side effects people have besides Posterior reversible encephalopathy syndrome? *

Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 5 people, 20.00%
Overdose: 5 people, 20.00%
Renal Infarct (kidney damage due to lack of blood supply): 5 people, 20.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 16.00%
Acute Chest Syndrome (acute chest pain, fever and difficulty breathing): 4 people, 16.00%
Headache (pain in head): 4 people, 16.00%
Systemic Inflammatory Response Syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection): 4 people, 16.00%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 3 people, 12.00%
Weakness: 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 3 people, 12.00%
Pain: 3 people, 12.00%
Vasculitis (inflammation of a blood vessel or blood vessels): 2 people, 8.00%
Stress And Anxiety: 2 people, 8.00%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 8.00%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 2 people, 8.00%
Headache (pain in head): 2 people, 8.00%
Neuralgia (pain in one or more nerves): 2 people, 8.00%
Undifferentiated Connective Tissue Disease: 2 people, 8.00%
Body Temperature Increased: 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Posterior reversible encephalopathy syndrome?

- Check whether Posterior reversible encephalopathy syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Posterior reversible encephalopathy syndrome treatments and more:

Posterior reversible encephalopathy syndrome (9,125 reports)

How severe was Posterior reversible encephalopathy syndrome and when was it recovered:

Posterior reversible encephalopathy syndrome in Hydramine

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Posterior reversible encephalopathy syndrome and drugs with ingredients of diphenhydramine hydrochloride (45 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Posterior reversible encephalopathy syndrome:

Posterior reversible encephalopathy syndrome (467 drugs)

Browse all the conditions that are associated with Posterior reversible encephalopathy syndrome:

Posterior reversible encephalopathy syndrome (1,010 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.