Hydramine and Vital functions abnormal - a phase IV clinical study of FDA data

Summary:

Vital functions abnormal is reported as a side effect among people who take Hydramine (diphenhydramine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Aranesp, and have Retroperitoneal fibrosis.

The phase IV clinical study analyzes which people have Vital functions abnormal when taking Hydramine. It is created by eHealthMe based on reports of 113,450 people who have side effects when taking Hydramine from the FDA, and is updated regularly.

What is Hydramine?

Hydramine has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 114,900 Hydramine users. Check the latest studies of Hydramine.

What is Vital functions abnormal?

Vital functions abnormal is found to be associated with 129 drugs and 189 conditions by eHealthMe. Check the latest studies of Vital functions abnormal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

113,450 people reported to have side effects when taking Hydramine.
Among them, 32 people (0.03%) have Vital functions abnormal.

Could Hydramine cause Vital functions abnormal?

Among these 32 people:

How long have people been on Hydramine when they have Vital functions abnormal? *

What is the gender of people who have Vital functions abnormal when taking Hydramine? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Vital functions abnormal when taking Hydramine? *

What are other drugs people take besides Hydramine? *

What are other side effects people have besides Vital functions abnormal? *

Dyspnea (difficult or laboured breathing): 18 people, 56.25%
High Blood Pressure: 16 people, 50.00%
Back Pain: 15 people, 46.88%
Oedema Peripheral (superficial swelling): 11 people, 34.38%
Renal Impairment (severely reduced kidney function): 11 people, 34.38%
Renal Cyst (kidney cyst): 11 people, 34.38%
Renal Artery Stenosis (narrowing of renal artery): 11 people, 34.38%
Diarrhea: 11 people, 34.38%
Drug Hypersensitivity: 11 people, 34.38%
Abdominal Distension: 11 people, 34.38%

What are the existing conditions these people have? *

Retroperitoneal Fibrosis (a rare disorder that occurs when extra fibrous tissue forms in the area behind the stomach and intestines): 11 people, 34.38%
Granuloma (a small area of inflammation due to tissue injury): 10 people, 31.25%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 28.12%
Suicide Attempt: 1 person, 3.12%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.12%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 3.12%
Post Procedural Pain: 1 person, 3.12%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Hydramine and have Vital functions abnormal?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydramine:

Hydramine (114,900 reports)

Browse all side effects of Hydramine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vital functions abnormal:

Vital functions abnormal (129 drugs)

Browse all the conditions that are associated with Vital functions abnormal:

Vital functions abnormal (189 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Hydramine) and Hydramine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.