Hydrochlorothiazide and Application site vesicles - a phase IV clinical study of FDA data

Summary:

Application site vesicles is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Metformin, and have Anogenital warts.

The phase IV clinical study analyzes which people have Application site vesicles when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Application site vesicles?

Application site vesicles (small bubble within a cell at application site) is found to be associated with 273 drugs and 570 conditions by eHealthMe. Check the latest studies of Application site vesicles.

On Jul, 13, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 72 people (0.04%) have Application site vesicles.

Could Hydrochlorothiazide cause Application site vesicles?

Among these 72 people:

What is the gender of people who have Application site vesicles when taking Hydrochlorothiazide? *

female: 78.57 %
male: 21.43 %

What is the age of people who have Application site vesicles when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

What are other side effects people have besides Application site vesicles? *

Application Site Erythema (redness of the skin at application site): 35 people, 48.61%
Application Site Pruritus (application site severe itching of the skin): 25 people, 34.72%
Application Site Pain: 21 people, 29.17%
Anogenital Warts: 10 people, 13.89%
Vulvovaginal Pain: 10 people, 13.89%
Skin Plaque (red, scaly patches to appear on the skin): 10 people, 13.89%
Application Site Discharge: 9 people, 12.50%
Application Site Rash: 9 people, 12.50%
Diarrhea: 8 people, 11.11%
Fatigue (feeling of tiredness): 7 people, 9.72%

What are the existing conditions these people have? *

Anogenital Warts: 10 people, 13.89%
Actinic Keratosis (skin disease due to sun exposure): 7 people, 9.72%
Pain: 7 people, 9.72%
Mycosis Fungoides (lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin): 7 people, 9.72%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 8.33%
Stress And Anxiety: 5 people, 6.94%
High Blood Cholesterol: 5 people, 6.94%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.56%
Hypersensitivity: 3 people, 4.17%
Insomnia (sleeplessness): 3 people, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Application site vesicles?

- Check whether Application site vesicles is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site vesicles:

Application site vesicles (273 drugs)

Browse all the conditions that are associated with Application site vesicles:

Application site vesicles (570 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.