Hydrochlorothiazide and Maculopathy - a phase IV clinical study of FDA data

Summary:

Maculopathy is reported as a side effect among people who take Hydrochlorothiazide (hydrochlorothiazide), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Elmiron, and have Cystitis interstitial.

The phase IV clinical study analyzes which people have Maculopathy when taking Hydrochlorothiazide. It is created by eHealthMe based on reports of 177,544 people who have side effects when taking Hydrochlorothiazide from the FDA, and is updated regularly.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

What is Maculopathy?

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest) is found to be associated with 378 drugs and 732 conditions by eHealthMe. Check the latest studies of Maculopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

177,544 people reported to have side effects when taking Hydrochlorothiazide.
Among them, 84 people (0.05%) have Maculopathy.

Could Hydrochlorothiazide cause Maculopathy?

Among these 84 people:

How long have people been on Hydrochlorothiazide when they have Maculopathy? *

What is the gender of people who have Maculopathy when taking Hydrochlorothiazide? *

female: 87.95 %
male: 12.05 %

What is the age of people who have Maculopathy when taking Hydrochlorothiazide? *

What are other drugs people take besides Hydrochlorothiazide? *

What are other side effects people have besides Maculopathy? *

Visual Acuity Reduced (reduced clearness of vision): 9 people, 10.71%
Retinopathy (acute damage to the retina of the eye): 9 people, 10.71%
Age-Related Macular Degeneration: 8 people, 9.52%
Cataract (clouding of the lens inside the eye): 8 people, 9.52%
High Blood Cholesterol: 8 people, 9.52%
Visual Field Defect: 8 people, 9.52%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 7 people, 8.33%
Atherosclerosis (disorder of the arteries): 6 people, 7.14%
Retinal Depigmentation (change in colour of retina): 6 people, 7.14%
Visual Impairment: 6 people, 7.14%

What are the existing conditions these people have? *

Cystitis Interstitial (unknown cause characterized by bladder pain): 54 people, 64.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 21.43%
High Blood Cholesterol: 17 people, 20.24%
Pain: 17 people, 20.24%
Depression: 16 people, 19.05%
Asthma: 14 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 11 people, 13.10%
Stress And Anxiety: 11 people, 13.10%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 10.71%
Thyroid Diseases: 9 people, 10.71%

* Approximation only. Some reports may have incomplete information.

Do you take Hydrochlorothiazide and have Maculopathy?

- Check whether Maculopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Hydrochlorothiazide:

Hydrochlorothiazide (182,194 reports)

Maculopathy treatments and more:

Maculopathy (5,625 reports)

Browse all side effects of Hydrochlorothiazide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Maculopathy:

Maculopathy (378 drugs)

Browse all the conditions that are associated with Maculopathy:

Maculopathy (732 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Hydrochlorothiazide) and Hydrochlorothiazide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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